Department of Pharmacy, Hospital San Agustín, Heros s/n, 33400 Avilés, Spain.
J Orthop Res. 2013 Dec;31(12):2025-31. doi: 10.1002/jor.22450. Epub 2013 Jul 24.
The elevation of metal levels in serum and urine during post-operative follow-up is a frequent find following the implantation of certain models of metal-on-metal hip prostheses. Among 45 patients with the same resurfacing prostheses, chromium (Cr) and cobalt (Co) levels in serum and urine were determined at 3, 4, 5, and 6 years after surgery. In the same period, levels of Cr, Co and molibdene (Mo) in scalp hair were also measured. Mean Cr and Co levels in serum were 8.29 µg/L (SD 17.97) and 8.38 µg/L (SD 21.97), respectively, whereas in urine levels were 16.20 µg/L (SD SD 32.55) and 75.40 µg/L (SD 190.86), respectively. In hair, mean Cr level were 163.27 µg/g (SD 300.62), mean Co level 61.98 µg/g (SD 126.48), and Mo 31.36 µg/g (SD 37.86). A high concordance was observed between chromium-urine and chromium-serum and between cobalt-urine and cobalt-hair. A moderate concordance was present between cobalt-urine and cobalt-serum, and between cobalt-hair and cobalt-serum. Eleven patients required revision surgery, five of them due to metallosis and periarticular cyst. At 1 year after reintervention, analytics were performed again and the following decrease rates were found: 42.8% in Cr levels, 51.1% in Mo levels, and 90.3% in Co levels.
在植入某些金属对金属髋关节假体后，在术后随访期间，血清和尿液中的金属水平升高是一种常见现象。在 45 名接受相同表面置换假体的患者中，在手术后 3、4、5 和 6 年时测定了血清和尿液中的铬（Cr）和钴（Co）水平。在同一时期，还测量了头皮头发中的 Cr、Co 和钼（Mo）水平。血清中 Cr 和 Co 的平均水平分别为 8.29 µg/L（SD 17.97）和 8.38 µg/L（SD 21.97），而尿液中的水平分别为 16.20 µg/L（SD 32.55）和 75.40 µg/L（SD 190.86）。头发中的 Cr 平均水平为 163.27 µg/g（SD 300.62），Co 平均水平为 61.98 µg/g（SD 126.48），Mo 平均水平为 31.36 µg/g（SD 37.86）。Cr-尿和 Cr-血清之间以及 Co-尿和 Co-头发之间存在高度一致性。Co-尿和 Co-血清之间以及 Co-头发和 Co-血清之间存在中度一致性。有 11 名患者需要进行翻修手术，其中 5 例由于金属中毒和关节周围囊肿。在再次干预后 1 年，再次进行了分析，发现以下下降率：Cr 水平下降 42.8%，Mo 水平下降 51.1%，Co 水平下降 90.3%。
