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年轻且活跃的金属对金属髋关节假体患者的母乳金属离子水平。

Breast milk metal ion levels in a young and active patient with a metal-on-metal hip prosthesis.

机构信息

Department of Orthopaedic Surgery, St. Elisabeth Hospital, Tilburg, the Netherlands.

出版信息

J Arthroplasty. 2013 Jan;28(1):196.e19-22. doi: 10.1016/j.arth.2012.06.013. Epub 2012 Aug 3.

Abstract

Metal-on-metal resurfacing arthroplasty of the hip has been used increasingly over the last 10 years in younger active patients. The dissolution of the metal wear particles results in measurable increases in cobalt and chromium ions in the serum and urine of patients with a metal-on-metal bearing. We measured the cobalt, chromium, and molybdenum ion levels in urine; serum; and breast milk in a young and active patient with a metal-on-metal hip prosthesis after a pathologic fracture of the femoral neck. Metal-on-metal hip prosthesis leads to increasing levels of molybdenum in breast milk in the short-term follow-up. There are no increasing levels of chromium and cobalt ions in breast milk. Besides the already known elevated concentrations in serum of chromium and cobalt after implantation of a metal-on-metal hip prosthesis, we found no increasing levels of chromium and cobalt in urine.

摘要

在过去的 10 年中,金属对金属表面置换髋关节成形术在年轻、活跃的患者中越来越多地被使用。金属磨损颗粒的溶解会导致金属对金属轴承患者的血清和尿液中钴和铬离子的可测量增加。我们在一位年轻且活跃的金属对金属髋关节假体患者发生股骨颈病理性骨折后,测量了其尿液、血清和母乳中的钴、铬和钼离子水平。金属对金属髋关节假体导致短期内母乳中钼含量增加。母乳中铬和钴离子水平没有增加。除了金属对金属髋关节假体植入后已经知道的铬和钴在血清中的浓度升高外,我们在尿液中也没有发现铬和钴浓度升高。

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