非洲猪瘟病毒胸苷激酶的序列与进化关系
Sequence and evolutionary relationships of African swine fever virus thymidine kinase.
作者信息
Blasco R, López-Otín C, Muñóz M, Bockamp E O, Simón-Mateo C, Viñuela E
机构信息
Centro de Biología Molecular (CSIC-UAM), Facultad de Ciencias, Universidad Autónoma, Canto Blanco, Madrid, Spain.
出版信息
Virology. 1990 Sep;178(1):301-4. doi: 10.1016/0042-6822(90)90409-k.
Abstract
The thymidine kinase gene of African swine fever virus was mapped in a 1.4-kb EcoRI-PstI fragment located in the left half of the Eco RI K fragment of African swine fever virus DNA by using degenerate oligonucleotide probes derived from regions of the thymidine kinase sequence conserved in several poxviruses, man, mouse, and chicken. The nucleotide sequence of this region revealed an open reading frame of 196 codons, whose translated amino acid sequence showed significant similarity to the thymidine kinases of vaccinia virus, variola virus, monkeypox virus, shope fibroma virus, fowlpox virus, capripox virus, man, mouse, and chicken. The similarity scores obtained after comparison of known thymidine kinase sequences indicated that the African swine fever virus thymidine kinase is more distantly related than the poxvirus thymidine kinases to their cellular homologs. The evolutionary implications of these findings are discussed.
摘要
通过使用从几种痘病毒、人、小鼠和鸡中保守的胸苷激酶序列区域衍生的简并寡核苷酸探针，将非洲猪瘟病毒的胸苷激酶基因定位在非洲猪瘟病毒DNA的Eco RI K片段左半部分的一个1.4kb的EcoRI - PstI片段中。该区域的核苷酸序列揭示了一个由196个密码子组成的开放阅读框，其翻译后的氨基酸序列与痘苗病毒、天花病毒、猴痘病毒、肖普纤维瘤病毒、禽痘病毒、山羊痘病毒、人、小鼠和鸡的胸苷激酶具有显著相似性。比较已知胸苷激酶序列后获得的相似性得分表明，非洲猪瘟病毒胸苷激酶与其细胞同源物的关系比痘病毒胸苷激酶更远。讨论了这些发现的进化意义。
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