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非洲猪瘟病毒的三个相邻基因,与痘病毒必需基因具有相似性。

Three adjacent genes of African swine fever virus with similarity to essential poxvirus genes.

作者信息

Roberts P C, Lu Z, Kutish G F, Rock D L

机构信息

Plum Island Animal Disease Center, USDA, ARS, NAA, Greenport, New York.

出版信息

Arch Virol. 1993;132(3-4):331-42. doi: 10.1007/BF01309543.

DOI:10.1007/BF01309543
PMID:8397501
Abstract

Nucleotide sequencing of the right end of the SalIj fragment of the highly virulent Malawi Lil20/1 strain of African swine fever virus (ASFV) has revealed three adjacent genes with similarity to: serine-threonine protein kinases; members of the putative helicase superfamily SF2; and the vaccinia virus 56 kDa abortive late protein. All three genes are transcribed to the left with respect to the orientation of the ASFV genome. Gene L19IL predicts a protein similar to serine-threonine protein kinases including vaccinia virus gene B1R. Gene L19KL predicts a protein that is likely to be a nucleic acid-dependent ATPase, as it has similarity to both the poxvirus 70 kDa early transcription factor subunit and the poxvirus nucleoside triphosphatase I gene. Gene L19LL has extensive similarity to the vaccinia virus 56 kDa abortive late protein.

摘要

对高致病性非洲猪瘟病毒(ASFV)马拉维Lil20/1株的SalIj片段右端进行核苷酸测序,结果显示有三个相邻基因,它们分别与以下基因相似:丝氨酸 - 苏氨酸蛋白激酶;假定解旋酶超家族SF2的成员;以及痘苗病毒56 kDa流产晚期蛋白。相对于ASFV基因组的方向,这三个基因均向左转录。基因L19IL预测的蛋白质与丝氨酸 - 苏氨酸蛋白激酶相似,包括痘苗病毒基因B1R。基因L19KL预测的蛋白质可能是一种依赖核酸的ATP酶,因为它与痘苗病毒70 kDa早期转录因子亚基和痘苗病毒核苷三磷酸酶I基因都有相似性。基因L19LL与痘苗病毒56 kDa流产晚期蛋白有广泛的相似性。

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本文引用的文献

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6
Resistance of vaccinia virus to interferon is related to an interference phenomenon between the virus and the interferon system.痘苗病毒对干扰素的抗性与病毒和干扰素系统之间的干扰现象有关。
Virology. 1984 Apr 15;134(1):12-28. doi: 10.1016/0042-6822(84)90268-x.
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Nucleoside triphosphate phosphohydrolase activities in African swine fever virus.非洲猪瘟病毒中的核苷三磷酸磷酸水解酶活性
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