Centro de Ciências Moleculares e Materiais, Departamento de Química e Bioquímica Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal.
J Inorg Biochem. 2013 Oct;127:79-81. doi: 10.1016/j.jinorgbio.2013.07.002. Epub 2013 Jul 12.
d-glucose end-capped polylactide ruthenium cyclopentadienyl complex (RuPMC) was newly synthesized by a straightforward method. RuPMC was tested against human MCF7 and MDAMB231 breast and A2780 ovarian adenocarcinoma revealing IC50 values in the micromolar range. A pH dependent hydrolysis is advanced by preliminary UV-visible spectroscopy. Cellular distribution studies showed that RuPMC is predominantly found in the nucleus and in the membrane. Data suggest potential application of RuPMC as a new drug delivery system for Ru(II)Cp compounds.
d-葡萄糖封端聚乳酸钌茂配合物（RuPMC）采用简单方法新合成。RuPMC 对人 MCF7 和 MDAMB231 乳腺癌和 A2780 卵巢腺癌进行了测试，显示出微摩尔范围内的 IC50 值。初步的紫外可见光谱表明，RuPMC 具有 pH 依赖性水解。细胞分布研究表明，RuPMC 主要存在于细胞核和细胞膜中。数据表明，RuPMC 可作为 Ru(II)Cp 化合物的新型药物传递系统的潜在应用。
