Clauser M, Altenberger J
Pensionsversicherungsanstalt, Sonderkrankenanstalt Rehabilitationszentrum Großgmain für Herz-Kreislauf- und neurologische Erkrankungen, Salzburgerstr. 520, A-5084, Großgmain, Österreich.
Herz. 2013 Sep;38(6):610-7. doi: 10.1007/s00059-013-3885-0.
Obesity as well as cardiac cachexia in heart failure patients are not fully understood and therefore of high scientific interest. Obesity as a common risk factor for cardiovascular disease is associated with a high mortality. In contrast obesity in patients suffering from chronic heart failure seems to be accompanied with a favorable outcome in contrast to people with normal weight, known as the obesity paradox. In the last decade there has been growing interest in cachexia, which is common in advanced stages of chronic diseases, such as heart failure, chronic obstructive pulmonary disease (COPD), cancer and renal failure and is associated with a poor prognosis. Until now cachexia has been underdiagnosed and undertreated. This review discusses the complex underlying pathomechanisms as well as potential therapeutic approaches.
心力衰竭患者的肥胖以及心源性恶病质尚未被完全理解，因此具有很高的科学研究价值。肥胖作为心血管疾病的常见危险因素，与高死亡率相关。相比之下，慢性心力衰竭患者的肥胖似乎与体重正常者相比有着较好的预后，这被称为肥胖悖论。在过去十年中，人们对恶病质的兴趣日益浓厚，恶病质在慢性疾病的晚期很常见，如心力衰竭、慢性阻塞性肺疾病（COPD）、癌症和肾衰竭，并且与不良预后相关。到目前为止，恶病质一直未得到充分诊断和治疗。本综述讨论了其复杂的潜在病理机制以及潜在的治疗方法。
