胎盘 IGF-1 和 IGFBP-3 的表达与产前电子废物暴露相关的脐血 PAH 和 PBDE 水平相关。
Placental IGF-1 and IGFBP-3 expression correlate with umbilical cord blood PAH and PBDE levels from prenatal exposure to electronic waste.
机构信息
Analytical Cytology Laboratory, Shantou University Medical College, 22 Xinling Rd., Shantou 515041, Guangdong, China; Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou 515041, China; Department of Cell Biology and Genetics, Shantou University Medical College, Shantou 515041, China.
出版信息
Environ Pollut. 2013 Nov;182:63-9. doi: 10.1016/j.envpol.2013.07.005. Epub 2013 Jul 27.
Electronic waste recycling produces Polycyclic Aromatic Hydrocarbons (PAHs) and Polybrominated Diphenyl Ethers (PBDEs) which may affect fetal growth and development by altering the insulin-like-growth factor (IGF) system. Questionnaires were administered to pregnant women (Guiyu, an e-waste site, n = 101; control, n = 53), and umbilical cord blood (UCB) and placentas were collected upon delivery. PBDEs and PAHs in UCB and placental IGF-1 and IGFBP-3 mRNA levels were analyzed using GC-MS and real-time PCR, respectively. Infant birth length and Apgar scores were lower in Guiyu. All PAHs (except Fl, Chr, IP, BbF and BP), total 16-PAHs, total/individual PBDEs, placental IGF-1 (median 0.23 vs 0.19; P < 0.05) and IGFBP-3 (median 1.91 vs 0.68; P < 0.001) levels were significantly higher in Guiyu. Spearman correlation showed that BDE-154, BDE-209 and ∑5ring-PAHs positively correlate with IGF-1 while PBDEs, 4 rings and total PAHs correlate with IGFBP-3 expression. Increased placental IGF-1 level might indirectly affect fetal growth and development.
电子垃圾回收会产生多环芳烃 (PAHs) 和多溴二苯醚 (PBDEs)，这些物质可能通过改变胰岛素样生长因子 (IGF) 系统来影响胎儿的生长和发育。我们向孕妇（贵屿，一个电子垃圾场，n = 101；对照组，n = 53）发放了问卷，并在分娩时收集了脐血 (UCB) 和胎盘。使用 GC-MS 和实时 PCR 分别分析了 UCB 和胎盘 IGF-1 和 IGFBP-3 mRNA 水平中的 PBDEs 和 PAHs。贵屿组的婴儿出生长度和阿普加评分较低。除 Fl、Chr、IP、BbF 和 BP 外的所有 PAHs（总计 16 种 PAHs、总/个体 PBDEs、胎盘 IGF-1（中位数 0.23 比 0.19；P < 0.05）和 IGFBP-3（中位数 1.91 比 0.68；P < 0.001）水平在贵屿显著升高。Spearman 相关性分析表明，BDE-154、BDE-209 和∑5 环-PAHs 与 IGF-1 呈正相关，而 PBDEs、4 环和总 PAHs 与 IGFBP-3 表达呈正相关。胎盘 IGF-1 水平升高可能会间接影响胎儿的生长和发育。
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