Zeng Xiao-Feng, Li Juan, Li Sheng-Bin
School of Forensic Medicine, Xi'an Jiaotong University, Xi'an, Shanxi Province, China.
Tumour Biol. 2014 Jan;35(1):265-8. doi: 10.1007/s13277-013-1034-2. Epub 2013 Jul 31.
Accumulating evidence has identified that polymorphism residing in the microRNA (miRNA) binding site of target genes can affect the strength of miRNA binding and influence individual susceptibility to cancer. Recently, an insertion/deletion polymorphism (rs3783553 ttca/-) at miRNA-122 binding site in the interleukin-1A 3' untranslated region has been demonstrated to be functional. We aimed to investigate the association between the rs3783553 polymorphism and the risk of gastric cancer (GC). We genotyped the rs3783553 polymorphism in 207 GC patients and 381 healthy controls by using a polymerase chain reaction method. We found that the ins/ins (ttca/ttca) genotype of the rs3783553 polymorphism was associated with a significantly decreased risk of GC (P = 0.02, odds ratio = 0.48, 95% confidence interval 0.26-0.90). This finding suggests that the rs3783553 polymorphism may be a protective factor for the development of GC.
越来越多的证据表明，位于靶基因微小RNA（miRNA）结合位点的多态性可影响miRNA结合的强度，并影响个体对癌症的易感性。最近，已证明白细胞介素-1A 3'非翻译区中miRNA-122结合位点的插入/缺失多态性（rs3783553 ttca/-）具有功能。我们旨在研究rs3783553多态性与胃癌（GC）风险之间的关联。我们采用聚合酶链反应方法对207例GC患者和381例健康对照者的rs3783553多态性进行基因分型。我们发现，rs3783553多态性的ins/ins（ttca/ttca）基因型与GC风险显著降低相关（P = 0.02，比值比= 0.48，95%置信区间0.26 - 0.90）。这一发现表明，rs3783553多态性可能是GC发生的一个保护因素。
