Sopi Ramadan B, Hayat Khan Muhammad Feroz
Department of Pharmacy-Biology, University of Prishtina, Prishtina, Kosovo.
Pharmacognosy Res. 2013 Jul;5(3):169-72. doi: 10.4103/0974-8490.112422.
Nyctanthes arbortristis has been used in traditional medicine for the treatment of asthma and cough.
In this study, bronchodilatory effect of ethanolic extract of the N. arbortristis was investigated under in vitro conditions. The concentration-response curve of the tracheal smooth muscle (TSM) to histamine was recorded in presence or absence of ethanolic extract and N(ω)-nitro-l-arginine methyl ester (L-NAME). Dose-response effect of ethanolic extract on pre-constricted tissues was investigated. The ethanolic extract inhibited the histamine-induced maximum contractile responses of TSM (P < 0.001). Ethanolic extract also cause dose-dependent relaxation of TSM. These effects were reversed by L-NAME. Phytochemical analysis showed the presence of typical plant constituents. These results suggest the possible use of extract of the leaves of N. arbortristis as a bronchodilator in therapeutic treatment of asthma.
夜花树在传统医学中用于治疗哮喘和咳嗽。
本研究在体外条件下研究了夜花树乙醇提取物的支气管扩张作用。在有或没有乙醇提取物和N（ω）-硝基-L-精氨酸甲酯（L-NAME）的情况下，记录气管平滑肌（TSM）对组胺的浓度-反应曲线。研究了乙醇提取物对预收缩组织的剂量-反应效应。乙醇提取物抑制了组胺诱导的TSM最大收缩反应（P <0.001）。乙醇提取物还引起TSM的剂量依赖性舒张。这些作用被L-NAME逆转。植物化学分析表明存在典型的植物成分。这些结果表明，夜花树叶片提取物可能作为支气管扩张剂用于哮喘的治疗。
