Patel Muhammad Junaid, Ahmer Syed, Khan Faheem, Qureshi Abdullah Waqar Ahmed, Shehzad Muhammad Farrukh, Muzaffar Sania
Department of Internal Medicine, Aga Khan University Hospital, Karachi.
J Pak Med Assoc. 2013 Jun;63(6):717-20.
To estimate the prevalence of Benzodiazepine use in the outpatient setting of general medicine clinics at a single tertiary care centre.
The prospective prevalence study was conducted in the outpatient setting of Internal Medicine Clinics at Aga Khan University Hospital, Karachi, from November to December 2009. All subjects were interviewed after informed consent and variables were recorded on a specially-designed proforma. Apart from basic demographics and comorbid conditions, duration, frequency and route of benzodiazepine use, as well as the reason and who initiated it was noted. Chi-square test and t test was applied to see the association of socio demographic or clinical factors with the use of benzodiazepine.
Of the 355 patients, 129 (36.33%) reported using the drug. The majority (n=86; 24.2%) were taking it on a daily basis. The highest numbers of patients using the drug were suffering from cardiovascular problems, 32 (25%) followed by 22 (17%) from endocrinology. Diazepam equivalent dose was around 7.04+4, with a inter-quartile range of 3-96 weeks. Alprazolam (9%) was the most frequently prescribed Benzodiazepine.
Benzodiazepine use is alarmingly high in the outpatient clinics of General Internal Medicine Department. There is no implementation of law to prevent its hazardous sale. In this regard all concerned should work collectively for awareness and irrational drug sale and use.
评估在一家三级医疗中心的普通内科门诊中苯二氮䓬类药物的使用 prevalence。
2009年11月至12月，在卡拉奇阿迦汗大学医院内科门诊进行前瞻性 prevalence 研究。所有受试者在获得知情同意后接受访谈，并将变量记录在专门设计的表格上。除了基本人口统计学和共病情况外，还记录了苯二氮䓬类药物的使用 duration、频率和途径，以及使用原因和 initiator。应用卡方检验和t检验来观察社会人口统计学或临床因素与苯二氮䓬类药物使用之间的关联。
在355名患者中，129名（36.33%）报告使用过该药物。大多数（n = 86；24.2%）患者每天服用。使用该药物的患者中，心血管问题患者最多，有32名（25%），其次是内分泌科的22名（17%）。地西泮等效剂量约为7.04 + 4，四分位间距为3 - 96周。阿普唑仑（9%）是最常处方的苯二氮䓬类药物。
普通内科门诊中苯二氮䓬类药物的使用高得惊人。没有法律实施来防止其危险销售。在这方面，所有相关方应共同努力提高 awareness 并防止不合理的药物销售和使用。
