McHugh R Kathryn, Peckham Andrew D, Björgvinsson Thröstur, Korte Francesca M, Beard Courtney
McLean Hospital, 115 Mill Street, Belmont, MA, 02478, USA; Department of Psychiatry, Harvard Medical School, 25 Shattuck St., Boston, MA, 02115, USA.
McLean Hospital, 115 Mill Street, Belmont, MA, 02478, USA; Department of Psychiatry, Harvard Medical School, 25 Shattuck St., Boston, MA, 02115, USA.
J Psychiatr Res. 2020 Sep;128:33-37. doi: 10.1016/j.jpsychires.2020.05.020. Epub 2020 May 24.
Benzodiazepines are among the most commonly prescribed psychiatric medications and have the potential for misuse. People with psychiatric disorders may have a heightened liability to the reinforcing effects of benzodiazepines. Yet, the prevalence of benzodiazepine misuse in psychiatric care settings is not well characterized. The aim of the current study was to characterize the prevalence and correlates of benzodiazepine misuse in a sample of adults receiving psychiatric treatment (N = 589). The majority of participants reported a lifetime history of benzodiazepine prescription (68%) and 26% reported a lifetime history of misuse (defined as use without a prescription or at a dose or frequency higher than prescribed). Multivariable analyses indicated that history of a benzodiazepine prescription and drug use problems were significantly associated with lifetime benzodiazepine misuse. People with a history of benzodiazepine prescription had four times higher odds of misusing benzodiazepines and the primary source of misused benzodiazepines was from family or friends. Results suggest that benzodiazepine misuse is not exclusive to substance use disorder populations. The misuse of benzodiazepines should be assessed in psychiatric settings. Further research is needed to understand the impact of benzodiazepine misuse in this population and to develop tools to identify those at risk for misuse.
苯二氮䓬类药物是最常被处方的精神科药物之一,存在被滥用的可能性。患有精神疾病的人可能对苯二氮䓬类药物的强化作用更易产生依赖。然而,在精神科护理环境中苯二氮䓬类药物滥用的患病率尚未得到充分描述。本研究的目的是描述在接受精神科治疗的成年样本(N = 589)中苯二氮䓬类药物滥用的患病率及其相关因素。大多数参与者报告有苯二氮䓬类药物的终生处方史(68%),26%报告有终生滥用史(定义为无处方使用或使用剂量或频率高于规定)。多变量分析表明,苯二氮䓬类药物处方史和药物使用问题与终生苯二氮䓬类药物滥用显著相关。有苯二氮䓬类药物处方史的人滥用苯二氮䓬类药物的几率高出四倍,滥用的苯二氮䓬类药物的主要来源是家人或朋友。结果表明,苯二氮䓬类药物滥用并非仅见于物质使用障碍人群。在精神科环境中应评估苯二氮䓬类药物的滥用情况。需要进一步研究以了解苯二氮䓬类药物滥用对该人群的影响,并开发工具来识别有滥用风险的人群。