Zeng Xian-Lin, Li Jing-Feng, Yang Shu-Hua, Zheng Qi-Xin, Zou Zhen-Wei
Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
J Huazhong Univ Sci Technolog Med Sci. 2013 Aug;33(4):543-550. doi: 10.1007/s11596-013-1156-1. Epub 2013 Aug 1.
The purpose of the present study was to observe the structure and functional change of the bone-coating-prosthesis interface in vivo and to evaluate the histocompatibility of self-made prosthetic femoral components in the body and the degree of their bonding with the surrounding bone tissues as well as their stability. Six mature beagle dogs underwent bilateral hip replacement with prosthetic femur components. Three groups were established in terms of different coating of prothesis (four joints in each group): atmosphere (A) plasma-sprayed pure titanium (Ti) prosthetic joint with hydroxyapatite (HA) coating (HA+Ti+A group); vacuum (V) plasma-sprayed pure Ti prosthetic joint with HA coating (HA+Ti+V group); vacuum plasma-sprayed pure Ti prosthetic joint with Ti-HA stepped coating (Ti+HAG+Ti+V group). The hip joints were functionally evaluated, and subjected to X-ray examination, biomechanics inspection, and histological examination. As a result, X-ray imaging revealed all prosthetic joints were in a good location and no dislocation of joint was found. Shear strength of interface was significantly higher in Ti+HAG+Ti+V group than in HA+Ti+V group (P<0.05) and HA+Ti+A group (P<0.05) at 28th week. Histological examination showed the amount of newborn bone in Ti+HAG+Ti+V group was more than in HA+Ti+V group and HA+Ti+A group after 28 weeks. It was suggested that vacuum plasma-sprayed pure Ti prosthetic joint with TI-HA stepped coating could improve the bonding capacity of bone-prosthesis, enhance the stability of prosthesis, and increase the fixion of prosthetic femoral components because of better bone growth. This new type of biological material in prosthetic femoral components holds promises for application in clinical practice.
本研究旨在观察体内骨涂层-假体界面的结构和功能变化，评估自制人工股骨部件在体内的组织相容性、与周围骨组织的结合程度及其稳定性。6只成年比格犬接受了双侧人工股骨头置换术，使用人工股骨部件。根据假体不同涂层建立三组（每组四个关节）：大气（A）等离子喷涂纯钛（Ti）假体关节并带有羟基磷灰石（HA）涂层（HA+Ti+A组）；真空（V）等离子喷涂纯Ti假体关节并带有HA涂层（HA+Ti+V组）；真空等离子喷涂纯Ti假体关节并带有Ti-HA阶梯涂层（Ti+HAG+Ti+V组）。对髋关节进行功能评估，并进行X线检查、生物力学检测和组织学检查。结果，X线成像显示所有假体关节位置良好，未发现关节脱位。在第28周时，Ti+HAG+Ti+V组界面的剪切强度显著高于HA+Ti+V组（P<0.05）和HA+Ti+A组（P<0.05）。组织学检查显示，28周后Ti+HAG+Ti+V组新生骨量多于HA+Ti+V组和HA+Ti+A组。提示真空等离子喷涂纯Ti假体关节并带有TI-HA阶梯涂层可提高骨-假体的结合能力，增强假体稳定性，因骨生长更好而增加人工股骨部件的固定。这种新型生物材料在人工股骨部件中具有临床应用前景。
