Department of Neurosurgery, Kwong Wah Hospital, Kowloon, Hong Kong.
J Neurointerv Surg. 2014 Jun;6(5):394-9. doi: 10.1136/neurintsurg-2013-010813. Epub 2013 Jul 31.
Human placenta is a convenient resource for biomedical research, and has not yet been used for neurointerventional surgery research.
Our objective was to explore the feasibility of using human placenta to test various endovascular interventions and for training.
18 placentas soon after delivery were prepared for six pilot studies. (1) Study on anatomical similarity to human cerebral vessel. (2) Simulation of stent assisted coiling and flow diversion on an aneurysm model. (3) Simulation of intra-arterial thrombolysis. (4) Simulation of embolization of arteriovenous malformation with glues. (5) Simulation of mechanical thrombolysis and comparison of different devices. (6) Vascular model for training of neurointerventionalists.
When the chorionic plate vessels were compared with the cerebral cortical vessels, similarities were found in vascular branch patterns, histological cross sections, and angiographic appearances. Due to the semitransparency of its vessel wall, performance of flow diverter and stent assisted coiling of an aneurysm could be visualized under direct microscopic observation. Similarly, timing of clot lysis and glue polymerization could be estimated. Endothelial change after thrombectomy could be assessed by histological methods. From these pilot studies, the placenta model could be adopted to simulate various clinical situations. It is also ideal for interventional radiology training.
It is feasible to adopt the human placenta as an ex vivo vascular model in neurointerventional surgery research due to the fact that its vessels resemble the brain vasculature.
人体胎盘是生物医学研究的便利资源，但尚未用于神经介入手术研究。
我们的目的是探索使用人胎盘测试各种血管内介入治疗和培训的可行性。
在分娩后不久准备了 18 个胎盘进行了六项试点研究。(1)研究与人类脑血管的解剖相似性。(2)在动脉瘤模型上模拟支架辅助弹簧圈和血流转向。(3)模拟动脉内溶栓。(4)胶栓塞动静脉畸形的模拟。(5)模拟机械溶栓和比较不同设备。(6)用于神经介入医师培训的血管模型。
当比较绒毛板血管与大脑皮质血管时，在血管分支模式、组织学横切面和血管造影表现方面发现了相似性。由于其血管壁的半透明性，可以在直接显微镜观察下观察到血流转向器和支架辅助弹簧圈对动脉瘤的作用。同样，可以估计血栓溶解和胶聚合的时间。通过组织学方法可以评估血栓切除术后的内皮变化。通过这些初步研究，胎盘模型可以模拟各种临床情况。它也是介入放射学培训的理想选择。
由于胎盘的血管类似于脑血管，因此可以将其作为神经介入手术研究中的离体血管模型。
