胰腺癌患者中与癌症相关的肿瘤标志物CA 19-9和CA-50，特别提及Lewis血型状态
Cancer-associated tumour markers CA 19-9 and CA-50 in patients with pancreatic cancer with special reference to the Lewis blood cell status.
作者信息
Masson P, Pålsson B, Andrén-Sandberg A
机构信息
Dept of Clinical Chemistry, University Hospital, Lund, Sweden.
出版信息
Br J Cancer. 1990 Jul;62(1):118-21. doi: 10.1038/bjc.1990.241.
Abstract
Monoclonal antibodies 19-9 and C-50 were used to assay the cancer associated tumour antigens CA 19-9 and CA-50 in plasma from patients with confirmed pancreatic cancer, and related to the blood group and Lewis blood cell status. The plasma expressions of CA 19-9 or CA-50 were similar, including cases where the patients had Lewis phenotype Le (a-b-). However, analyses of both the tumour antigens could be used to differentiate the presence of cancer from its absence in Le (a-b-) individuals. The findings indicate that the targets for the monoclonal antibodies 19-9 and C-50 are similar. The practical implications of these findings are discussed.
摘要
使用单克隆抗体19-9和C-50检测确诊为胰腺癌患者血浆中的癌相关肿瘤抗原CA 19-9和CA-50，并将其与血型和Lewis血细胞状态相关联。CA 19-9或CA-50的血浆表达相似，包括患者具有Lewis表型Le（a-b-）的情况。然而，对这两种肿瘤抗原的分析可用于区分Le（a-b-）个体中癌症的存在与否。研究结果表明，单克隆抗体19-9和C-50的靶标相似。讨论了这些发现的实际意义。
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