Mahdani Fatma Yasmin, Subarnbhesaj Ajiravudh, Ayuningtyas Nurina Febriyanti, Surboyo Meircurius Dwi Condro, Bakti Reiska Kumala, Radithia Desiana, Paramananda Dimas Bayu, Indriyani Ina, Basalamah Fatimah Fauzi
Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Division of Oral Diagnosis, Department of Oral Biomedical Science, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand.
Eur J Dent. 2025 Feb;19(1):24-36. doi: 10.1055/s-0044-1788711. Epub 2024 Aug 5.
Diagnosing oral submucous fibrosis (OSMF) is invariably challenging. The disease can be detected after reaching its final stage and requires complex treatment. Changes in its salivary profile can be used as a reference to see this disorder and as a basis for diagnostic prediction. This study is aimed to analyze the salivary profile as a diagnosis marker in patients with OSMF. The study using Preferred Reporting Items for Systematic Reviews and Meta-analyses was conducted using PubMed, Science Direct, and Scopus databases. A thorough literature search between 1991 and 2023 was performed. Twenty-eight full-text articles were reviewed in detail. Twenty-eight articles were included; a total of 929 patients of OSMF and 826 controls were found. The scoping review showed that levels of salivary protein (including lactate hydrogenase, immunoglobulin G, immunoglobulin A, S1007A protein, 8-hydroxydeoxyguanosine, 8-isoprostane, malondialdehyde, matrix metalloproteinase-12, salivary C-reactive protein, fibrinogen producing factor, salivary miRNA-21, and salivary lipids [cholesterol, high-density lipoprotein, triglyceride) were higher in OSMF. Meanwhile, trace elements (vitamin C, vitamin E, iron, zinc, and magnesium) were lower; only copper was higher in OSMF patients. Alteration in salivary components such as protein, lipid, and trace elements detection can be a basis for providing a noninvasive supportive examination and thus be used as a diagnosis marker of OSMF.
诊断口腔黏膜下纤维化（OSMF）始终具有挑战性。该疾病在发展到终末期后才能被检测出来，并且需要复杂的治疗。其唾液成分的变化可作为观察这种疾病的参考以及诊断预测的依据。本研究旨在分析唾液成分作为OSMF患者的诊断标志物。本研究采用系统评价和Meta分析的首选报告项目，通过PubMed、Science Direct和Scopus数据库进行。对1991年至2023年间的文献进行了全面检索。对28篇全文文章进行了详细审查。纳入了28篇文章；共发现929例OSMF患者和826例对照。范围综述表明，OSMF患者的唾液蛋白水平（包括乳酸脱氢酶、免疫球蛋白G、免疫球蛋白A、S1007A蛋白、8-羟基脱氧鸟苷、8-异前列腺素、丙二醛、基质金属蛋白酶-12、唾液C反应蛋白、纤维蛋白原生成因子、唾液miRNA-21和唾液脂质[胆固醇、高密度脂蛋白、甘油三酯]）较高。同时，微量元素（维生素C、维生素E、铁、锌和镁）较低；只有铜在OSMF患者中较高。唾液成分如蛋白质、脂质和微量元素检测的改变可作为提供无创辅助检查的依据，从而用作OSMF的诊断标志物。
