Animal, Plant, and Fisheries Quarantine and Inspection Agency, 175 Anyang-ro, Manan-gu, Anyang 430-757, Republic of Korea.
J Food Prot. 2013 Aug;76(8):1443-6. doi: 10.4315/0362-028X.JFP-13-069.
Apramycin resistance was observed in 22.8% (81 of 355) of Salmonella Typhimurium isolates collected from pigs from 1998 through 2009 in Korea. All apramycin-resistant Salmonella Typhimurium isolates also were cross-resistant to gentamicin and tobramycin. Among the seven types of aminoglycoside resistance genes tested, only four types were detected in the apramycin-resistant Salmonella Typhimurium isolates: aac (3)-IV, aac (3)-II, aac (3)-III, and ant (2'')-I. Although the aac (3)-IV gene was found in all apramycin-resistant Salmonella Typhimurium isolates, aac (3)-II, aac (3)-III, and ant (2'')-I genes were detected in five (6.2%), two (2.5%), and three (3.7%) isolates, respectively. The apramycin-resistant isolates comprised six phage types, of which PT193 (16 of 81 isolates, 19.8%) was most commonly observed. To our knowledge, this is the first report describing characteristics of apramycin-resistant Salmonella Typhimurium isolates in Korea. Further study is warranted to determine whether apramycin use in animals results in cross-resistance to gentamicin, which may affect public health when gentamicin is required for disease treatment in humans.
1998 年至 2009 年期间，从韩国猪群中采集的 355 株鼠伤寒沙门氏菌分离株中，有 22.8%（81 株）表现出对安普霉素的耐药性。所有对安普霉素耐药的鼠伤寒沙门氏菌分离株对庆大霉素和妥布霉素也具有交叉耐药性。在测试的七种氨基糖苷类耐药基因中，仅在安普霉素耐药的鼠伤寒沙门氏菌分离株中检测到四种类型：aac(3)-IV、aac(3)-II、aac(3)-III 和 ant(2'')-I。尽管所有安普霉素耐药的鼠伤寒沙门氏菌分离株都发现了 aac(3)-IV 基因，但在五个（6.2%）、两个（2.5%）和三个（3.7%）分离株中分别检测到 aac(3)-II、aac(3)-III 和 ant(2'')-I 基因。安普霉素耐药分离株包括六种噬菌体型，其中 PT193（81 株分离株中的 16 株，19.8%）最为常见。据我们所知，这是首次在韩国描述安普霉素耐药鼠伤寒沙门氏菌分离株特征的报告。需要进一步研究以确定动物中安普霉素的使用是否导致对庆大霉素的交叉耐药性，这可能会影响人类在需要庆大霉素治疗疾病时的公共卫生。
