Department of Otolaryngology-Head & Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7070, USA.
Pediatr Clin North Am. 2013 Aug;60(4):979-91. doi: 10.1016/j.pcl.2013.04.001. Epub 2013 May 13.
Chronic rhinosinusitis (CRS) affects nearly 37 million people in the United States each year and accounts for approximately $6 billion in direct and indirect health care costs. Despite its prevalence and significant impact, little is known about its exact cause and pathophysiology, and significant controversy remains regarding appropriate treatment options. Basic science research, however, has shown recent promise toward improving understanding of the innate and environmental factors underlying the pathophysiology of CRS. The hope is that this will also lead to advances in treatment for children adversely affected by this common yet complicated disease.
慢性鼻-鼻窦炎（CRS）每年影响美国近 3700 万人，直接和间接医疗保健费用约为 60 亿美元。尽管它很普遍，对健康的影响也很大，但人们对其确切病因和病理生理学知之甚少，关于适当的治疗选择仍存在很大争议。然而，基础科学研究最近在改善对 CRS 病理生理学潜在的先天和环境因素的理解方面显示出了希望。人们希望这也将推动针对受这种常见但复杂疾病影响的儿童的治疗进展。
