与肺炎克雷伯菌特定序列类型相关的外膜孔蛋白K35和K36变体 - Suppr

OmpK35 and OmpK36 porin variants associated with specific sequence types of Klebsiella pneumoniae.

作者信息

Papagiannitsis Constantinos C, Giakkoupi Panagiota, Kotsakis Stathis D, Tzelepi Eva, Tzouvelekis Leonidas S, Vatopoulos Alkiviadis C, Miriagou Vivi

机构信息

Department of Microbiology, National School of Public Health, Athens 11521, Greece.

出版信息

J Chemother. 2013 Aug;25(4):250-4. doi: 10.1179/1973947813Y.0000000075.

DOI:10.1179/1973947813Y.0000000075

PMID:23906079

Abstract

摘要

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OmpK35 and OmpK36 porin variants associated with specific sequence types of Klebsiella pneumoniae.与肺炎克雷伯菌特定序列类型相关的外膜孔蛋白K35和K36变体

J Chemother. 2013 Aug;25(4):250-4. doi: 10.1179/1973947813Y.0000000075.

Characterization of the Genetic Background of KPC-2-Producing with Insertion Elements Disrupting the Porin Gene.产 KPC-2 酶与插入元件破坏孔蛋白基因的遗传背景特征。

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The mechanism of high-level carbapenem resistance in Klebsiella pneumoniae: underlying Ompk36-deficient strains represent a threat of emerging high-level carbapenem-resistant K. pneumoniae with IMP-1 β-lactamase production in Japan.高产碳青霉烯类耐药肺炎克雷伯菌的机制：产 IMP-1 型β-内酰胺酶的 OmpK36 缺陷株代表了日本高产碳青霉烯类耐药肺炎克雷伯菌的新威胁。

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Characteristics of carbapenem-resistant Enterobacteriaceae isolates from Korea.韩国碳青霉烯类耐药肠杆菌科分离株的特征。

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Reduced Susceptibility to Carbapenems in a Klebsiella pneumoniae Clinical Isolate Producing SCO-1 and CTX-M-15 β-Lactamases Together with OmpK35 and OmpK36 Porin Deficiency.一株同时产SCO-1和CTX-M-15β-内酰胺酶并伴有外膜孔蛋白OmpK35和OmpK36缺失的肺炎克雷伯菌临床分离株对碳青霉烯类药物敏感性降低

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Activity of β-lactam plus β-lactam-enhancer combination cefepime/zidebactam against Klebsiella pneumoniae harbouring defective OmpK35/36 porins and carbapenemases.β-内酰胺类药物联合β-内酰胺酶抑制剂头孢吡肟/齐多夫定对携带缺陷 OmpK35/36 孔蛋白和碳青霉烯酶的肺炎克雷伯菌的活性。

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In vivo selection of carbapenem-resistant Klebsiella pneumoniae by OmpK36 loss during meropenem treatment.在美罗培南治疗过程中 OmpK36 丢失导致耐碳青霉烯类肺炎克雷伯菌的体内选择。

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Emergence of carbapenem resistance due to porin loss in an extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae strain during meropenem therapy.在美罗培南治疗期间，产超广谱β-内酰胺酶（ESBL）的肺炎克雷伯菌菌株因孔蛋白缺失而出现碳青霉烯类耐药。

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Cephalosporin translocation across enterobacterial OmpF and OmpC channels, a filter across the outer membrane.头孢菌素经肠杆菌外膜孔蛋白 F 和 OmpC 通道的转运，该通道是外膜上的一道滤器。

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OmpK35 and OmpK36 porin variants associated with specific sequence types of Klebsiella pneumoniae.

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