Hershman J M, Eriksen E, Kaufman N, Champlin R E
Endocrine Research Laboratory, Wadsworth Veterans Administration Medical Center, Los Angeles, CA 90073.
Bone Marrow Transplant. 1990 Jul;6(1):49-51.
Thyroid function was studied prospectively in 27 patients receiving bone marrow transplants to determine the effect of this procedure and its sequelae on serum thyroid hormone levels and thyrotropin secretion. Serum triiodothyronine and free triiodothyronine concentrations declined to subnormal levels in nearly all of the patients; free thyroxine concentration became subnormal in 15 patients. At the time of the nadir of the serum T3 concentration, serum thyrotropin concentration, measured by a sensitive immunoradiometric assay, declined significantly and became subnormal in nine patients. The data suggest that the reduction of serum thyroxine levels after transplantation is attributable, at least in part, to inhibition of thyrotropin secretion.
对27例接受骨髓移植的患者进行了甲状腺功能的前瞻性研究，以确定该手术及其后遗症对血清甲状腺激素水平和促甲状腺激素分泌的影响。几乎所有患者的血清三碘甲状腺原氨酸和游离三碘甲状腺原氨酸浓度均降至正常水平以下；15例患者的游离甲状腺素浓度降至正常水平以下。在血清T3浓度最低点时，通过灵敏的免疫放射分析测定的血清促甲状腺激素浓度显著下降，9例患者降至正常水平以下。数据表明，移植后血清甲状腺素水平的降低至少部分归因于促甲状腺激素分泌的抑制。
