Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK.
Nat Cell Biol. 2013 Aug;15(8):887-9. doi: 10.1038/ncb2811.
Senescence, a cell-autonomous tumour suppressor mechanism, also has pro-tumorigenic effects on neighbouring pre-malignant cells through the senescence-associated secretory phenotype (SASP). The SASP is now shown to be regulated by inflammasomes and to induce paracrine senescence in healthy cells, indicating that senescence may also represent a non-cell-autonomous tumour suppressor mechanism linked to innate immunity.
衰老，一种细胞自主的肿瘤抑制机制，也通过衰老相关分泌表型（SASP）对邻近的癌前细胞产生促肿瘤作用。现在已经表明，SASP 受炎性小体调控，并诱导健康细胞的旁分泌衰老，这表明衰老也可能代表一种与先天免疫相关的非细胞自主肿瘤抑制机制。
