Shi M A, Chen Y L
Anhui Medical University, Hefei.
Zhonghua Fu Chan Ke Za Zhi. 1990 May;25(3):143-5, 187-8.
This paper described the epidemiological pattern and genetic features of congenital hydrocephalus. 77 214 births (live and still) were monitored, among whom 84 were hydrocephalus, incidence of 1.09%. The results suggested that the maternal occupation, age, number, of gravidity and educational level may be major contributors to the incidence of hydrocephalus. The incidence of hydrocephalus was significantly different between urban and rural areas, and its prevalence in the offsprings of parental consanguinity was 9.8%, being 9 times higher than those of non-consanguineous marriages (P less than 0.001). The incidence of hydrocephalus in the first degree relatives of the patient was 12.82%, being 10.76 times higher than that of the general population. The herebitability of the first degree relative was 49.6%.
本文描述了先天性脑积水的流行病学模式和遗传特征。监测了77214例出生情况（活产和死产），其中84例为脑积水，发病率为1.09%。结果表明，母亲的职业、年龄、妊娠次数和教育水平可能是脑积水发病率的主要影响因素。脑积水的发病率在城乡之间存在显著差异，其在近亲结婚后代中的患病率为9.8%，是非近亲结婚后代的9倍（P小于0.001）。患者一级亲属中脑积水的发病率为12.82%，是普通人群的10.76倍。一级亲属的遗传度为49.6%。
