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告诉我你吃什么,我就能说出你的社会类型:应对糖尿病肥胖症。

Tell me what you eat and I will tell you your sociotype: coping with diabesity.

作者信息

Berry Elliot M, De Geest Sabina

机构信息

Braun School of Public Health, Faculty of Medicine, Hebrew University of Jerusalem, Israel;

出版信息

Rambam Maimonides Med J. 2012 Apr 30;3(2):e0010. doi: 10.5041/RMMJ.10077. Print 2012 Apr.

Abstract

The term sociotype has been introduced to describe the dynamic relationship of an individual with his/her social environment throughout life. The sociotype is a conceptual framework to highlight, in addition to bio-medical pathways, the psycho-social and environmental factors necessary to understand responses to life stresses and patient self-management for chronic illness. The sociotype interacts with genotype expression through mate selection and metabolic programming, and with the phenotype to determine adaptation throughout life from birth to old age. Following on the work of Antonovsky, Engel, and McEwen, and others in the life and social sciences, the sociotype details and expands the many factors generally included in the environmental influences on a person's life identified here as the domains of health, relationships, and environment. Physiological mediators for sociotypic influences include: adrenal steroids and the sympathetic nervous system (allostatic load), and oxytocin (social neuroscience). The biological pathways are multiple through nutrition (essential dietary-derived amino- and fatty acids for neurotransmitter synthesis, caloric restriction, and diet-gene interactions), epigenesis, and metabolic programming. Nutrition influences growth and development, fertility and longevity, and also determines susceptibility to non-communicable diseases such as cardiovascular disease and cancer, and particularly diabetes and obesity, through in-utero effects, the development of intestinal flora (microbiome), and chronic stress. Thus the sociotype and nutrition are reciprocally related in both health and disease.

摘要

“社会型”这一术语已被引入,用于描述个体在其一生中与社会环境的动态关系。社会型是一个概念框架,除了生物医学途径外,还突出了理解对生活压力的反应和慢性病患者自我管理所需的心理社会和环境因素。社会型通过配偶选择和代谢编程与基因型表达相互作用,并与表型相互作用,以确定从出生到老年一生的适应情况。继安托诺夫斯基、恩格尔、麦克尤恩等人在生命和社会科学领域的研究工作之后,社会型详细阐述并扩展了通常包含在环境对人生活影响中的许多因素,这里将其确定为健康、人际关系和环境领域。社会型影响的生理介质包括:肾上腺类固醇和交感神经系统(应激负荷),以及催产素(社会神经科学)。生物学途径通过营养(用于神经递质合成的必需饮食衍生氨基酸和脂肪酸、热量限制以及饮食与基因相互作用)、表观遗传学和代谢编程等多种方式发挥作用。营养影响生长发育、生育能力和寿命,还通过子宫内效应、肠道菌群(微生物组)的发育以及慢性应激,决定对心血管疾病和癌症等非传染性疾病,尤其是糖尿病和肥胖症的易感性。因此,社会型和营养在健康和疾病方面相互关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62f7/3678814/de29bc008299/rmmj-3-2-e0010_Figure1.jpg

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