Huang Xiaoxia, Yin Hongmei, Yan Lei, Wang Xiaofang, Wang Shiwen
Both authors contributed equally in this article. ; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China .
Western Pac Surveill Response J. 2012 Feb 7;3(1):12-8. doi: 10.5365/WPSAR.2011.2.2.007. Print 2012 Jan.
To design effective prevention and control strategies for haemorrhagic fever with renal syndrome (HFRS) in Mainland China, we evaluated the epidemiologic characteristics and trends of HFRS cases reported between 2006 and 2010.
HFRS data from 1970 to 2010 were obtained from the China Notifiable Disease Reporting System (CNDRS). The cases analysed included clinical cases and laboratory-confirmed cases. Data was extracted for statistical analysis by time, region and profession; the incidence rate was obtained directly from CNDRS. In this study, we analysed the morbidity and mortality data of HFRS from 2006 to 2010.
HFRS cases trended downward from 2006 (15 098) to 2009 (8745), but exhibited a slight increase in 2010 (9526). Twenty-nine of 31 provinces reported HFRS cases between 2006 and 2010. Five provinces, namely, Heilongjiang, Jilin and Liaoning in the North-eastern, Shandong in the east, and Shaanxi in the central part of China, were characterized as high-endemic areas. Seasonal case distribution was bimodal, with peaks of cases in spring and winter. Young male farmers were the most susceptible population to HFRS. Early- to middle-aged adults (20-50 years old) represented the largest groups of HFRS cases.
The overall number of cases of HFRS in China has trended downward possibly due to national vaccine and rodent vector control programmes implemented in the past 25 years. However, this trend slowed down in the last five years. High-endemic regions and at-risk population groups still exist and will benefit from further targeted prevention strategies.
为制定中国大陆肾综合征出血热（HFRS）的有效防控策略，我们评估了2006年至2010年期间报告的HFRS病例的流行病学特征和趋势。
从中国法定传染病报告系统（CNDRS）获取1970年至2010年的HFRS数据。分析的病例包括临床病例和实验室确诊病例。按时间、地区和职业提取数据进行统计分析；发病率直接从CNDRS获取。在本研究中，我们分析了2006年至2010年HFRS的发病和死亡数据。
HFRS病例数从2006年的15098例呈下降趋势至2009年的8745例，但在2010年略有增加（9526例）。2006年至2010年期间，31个省份中有29个报告了HFRS病例。东北部的黑龙江、吉林和辽宁、东部的山东以及中部的陕西这五个省份为高流行区。病例的季节分布呈双峰型，春季和冬季为发病高峰。年轻男性农民是最易感染HFRS的人群。20至50岁的中青年人是HFRS病例的最大群体。
中国HFRS病例总数呈下降趋势，这可能归因于过去25年实施的国家疫苗和鼠媒控制计划。然而，在过去五年中这一趋势有所放缓。高流行地区和高危人群仍然存在，进一步的针对性预防策略将使他们受益。
