Chen H X, Qiu F X, Dong B J, Ji S Z, Li Y T, Wang Y, Wang H M, Zuo G F, Tao X X, Gao S Y
J Infect Dis. 1986 Sep;154(3):394-8. doi: 10.1093/infdis/154.3.394.
Hemorrhagic fever with renal syndrome (HFRS) has been reported from greater than 20 provinces in China. The number of reported cases has increased markedly in recent years and surpassed 80,000 human cases in 1983. All of the cases reported before 1981 were from rural areas and were attributed to Apodemus rats. In 1981, outbreaks of cases associated with house rats were first reported. Cases associated with Apodemus agrarius were more severe than those associated with the house rat Rattus norvegicus. The rate of inapparent infection in the rural population of areas endemic for Apodemus-associated disease was lower than that of Rattus-associated urban disease. After the onset of the disease, IgG antibody levels increase rapidly, peak after one week, and persist for as long as 25 years. Lung tissues from 16 species of rodent, from two species of sorex, and from cats and weasels in the epidemic areas have been found to carry antigen. A. agrarius, Apodemus peninsulae, and R. norvegicus serve as the main reservoirs of HFRS in rural areas, forest areas, and urban areas, respectively.
肾综合征出血热（HFRS）在中国20多个省份均有报告。近年来报告病例数显著增加，1983年超过8万例。1981年以前报告的所有病例均来自农村地区，归因于姬鼠。1981年首次报告了与家鼠相关的病例暴发。与黑线姬鼠相关的病例比与褐家鼠相关的病例更严重。黑线姬鼠相关疾病流行地区农村人口的隐性感染率低于褐家鼠相关城市疾病的隐性感染率。发病后，IgG抗体水平迅速升高，一周后达到峰值，并持续长达25年。在疫区，已发现16种啮齿动物、2种鼩鼱以及猫和鼬的肺组织携带抗原。黑线姬鼠、大林姬鼠和褐家鼠分别是农村地区、林区和城市地区肾综合征出血热的主要宿主。
