来自海南灵芝子实体的具有细胞毒性活性的羊毛甾烷三萜类化合物。
Lanostane triterpenoids with cytotoxic activities from the fruiting bodies of Ganoderma hainanense.
作者信息
Ma Qing-Yun, Luo Ying, Huang Sheng-Zhuo, Guo Zhi-Kai, Dai Hao-Fu, Zhao You-Xing
机构信息
a Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences , Haikou , 571101 , China.
出版信息
J Asian Nat Prod Res. 2013 Nov;15(11):1214-9. doi: 10.1080/10286020.2013.820712. Epub 2013 Aug 5.
Twelve lanostane triterpenoids (1-12) including a new one 16α,26-dihydroxylanosta-8,24-dien-3-one (1) were isolated from the fruiting bodies of Ganoderma hainanense. The structure of the new compound was elucidated by 1D and 2D NMR and MS spectroscopic analyses. All isolates were evaluated for their cytotoxicities against human tumor cell lines K-562, SMMC-7721, and SGC-7901 and five compounds (1, 2, 5,7, and 9) showed definite cytotoxicities against K-562 cell line. Meanwhile, compounds 2, 5,7, and 9 exhibited cytotoxic activities against SMMC-7721 and SGC-7901 cell lines.
从海南灵芝子实体中分离得到12个羊毛甾烷型三萜类化合物（1-12），其中包括一个新化合物16α,26-二羟基羊毛甾-8,24-二烯-3-酮（1）。通过一维和二维核磁共振及质谱光谱分析确定了该新化合物的结构。对所有分离物进行了针对人肿瘤细胞系K-562、SMMC-7721和SGC-7901的细胞毒性评估，有5个化合物（1、2、5、7和9）对K-562细胞系表现出一定的细胞毒性。同时，化合物2、5、7和9对SMMC-7721和SGC-7901细胞系表现出细胞毒活性。
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