茶褐灵芝中的三种新三萜类化合物。
Three new triterpenoids from Ganoderma theaecolum.
作者信息
Liu Li-Ying, Yan Zheng, Kang Jie, Chen Ruo-Yun, Yu De-Quan
机构信息
a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
出版信息
J Asian Nat Prod Res. 2017 Sep;19(9):847-853. doi: 10.1080/10286020.2016.1271793. Epub 2017 Feb 2.
Three new triterpenoids (1-3), together with four known triterpenoids (4-7), were isolated from the fruiting bodies of Ganoderma theaecolum. Their structures were elucidated on the basis of their spectroscopic data and chemical evidence. Compounds 4 and 6 exhibited antitumor activities against H460 cells with IC values of 22.4 and 43.1 μM, respectively. And the cytotoxic activities of compounds 4 and 5 against MDA-MB-231 cancer cell lines were assayed with IC values of 49.1 and 75.8 μM, respectively.
从茶状灵芝子实体中分离出三种新的三萜类化合物（1-3）以及四种已知的三萜类化合物（4-7）。根据它们的光谱数据和化学证据阐明了其结构。化合物4和6对H460细胞表现出抗肿瘤活性，IC值分别为22.4和43.1 μM。并且测定了化合物4和5对MDA-MB-231癌细胞系的细胞毒性活性，IC值分别为49.1和75.8 μM。
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