白肉层孔菌素A - R，来自白肉层孔菌的羊毛甾烷型三萜类化合物。
Leucocontextins A-R, lanostane-type triterpenoids from Ganoderma leucocontextum.
作者信息
Zhao Zhen-Zhu, Chen He-Ping, Li Zheng-Hui, Dong Ze-Jun, Bai Xue, Zhou Zhong-Yu, Feng Tao, Liu Ji-Kai
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, China.
School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
出版信息
Fitoterapia. 2016 Mar;109:91-8. doi: 10.1016/j.fitote.2015.12.004. Epub 2015 Dec 12.
Eighteen new lanostane-type triterpenoids, namely leucocontextins A-R (1-18) were isolated from the fruiting bodies of Ganoderma leucocontextum. Their structures were established by 1D and 2D NMR data in conjunction with HRESIMS/HREIMS, X-ray single crystal diffraction analysis. Compound 18 exhibited weak cytotoxicity against K562 and MCF-7 cell lines with IC50 of 20-30 μM.
从白肉灵芝子实体中分离得到18个新的羊毛甾烷型三萜类化合物，即白肉灵芝素A - R（1 - 18）。通过一维和二维核磁共振数据结合高分辨电喷雾电离质谱/高分辨电子轰击质谱、X射线单晶衍射分析确定了它们的结构。化合物18对K562和MCF - 7细胞系表现出较弱的细胞毒性，半数抑制浓度为20 - 30 μM。
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