DiSFeB, Department of Pharmacological and Biomolecular Sciences, University of Milan, via Balzaretti 9, Milan, Italy.
Prostaglandins Leukot Essent Fatty Acids. 2013 Sep;89(4):215-20. doi: 10.1016/j.plefa.2013.06.009. Epub 2013 Aug 1.
Long chain polyunsaturated fatty acids (LC-PUFA), especially the Omega 3, modulate key functions in the body. Their circulating levels are representative of their "status", and may vary at different ages. We have compared the FA status in Italian subjects from neonates to adulthood, assessed through FA analysis of blood drops from fingertips. Data from four cohorts of Italian subjects (total number 1835), have been pooled in four age-groups: neonates (4 days, n=81), children (2-9 years, n=728), adults (40-59 years, n=434) and elderly (60-79 years, n=592). LC-PUFA of both series (Omega 3 and 6) are higher in the blood of neonates than at subsequent ages, reflecting the efficient transfer of these FA from mothers to the fetus. In contrast, the lowest levels of Omega 3 PUFA, especially of DHA, are found in children, probably reflecting inadequate dietary intakes, with possible consequences on the health status at subsequent ages.
长链多不饱和脂肪酸（LC-PUFA），特别是欧米伽 3，调节着体内的关键功能。它们在血液中的循环水平代表了它们的“状态”，并且可能在不同年龄有所变化。我们通过指尖采血的 FA 分析，比较了意大利新生儿至成年期的 FA 状况。来自意大利四个队列的研究对象（总数为 1835 人）的数据，按四个年龄组进行了汇总：新生儿（4 天，n=81）、儿童（2-9 岁，n=728）、成年人（40-59 岁，n=434）和老年人（60-79 岁，n=592）。与后续年龄段相比，新生儿血液中的 LC-PUFA（欧米伽 3 和 6）含量更高，这反映了这些 FA 从母亲向胎儿的有效转移。相比之下，儿童血液中欧米伽 3 PUFA，尤其是 DHA 的含量最低，这可能反映了饮食摄入不足，可能对后续年龄段的健康状况产生影响。
