Nanotechnology and Advanced Materials Department, Materials & Energy Research Center, Alborz, Iran.
Mater Sci Eng C Mater Biol Appl. 2013 Oct;33(7):3730-44. doi: 10.1016/j.msec.2013.05.005. Epub 2013 May 9.
Bioactive glass nano-powders with the same chemical composition and different particle characteristics were synthesized by acid-catalyzed (the glass is called BG1) and acid-base catalyzed (BG2) sol-gel processes. Morphological characteristics of powders were determined by TEM and BET methods. The powders were separately mixed with 3% hyaluronic acid solution to form a paste. In vitro reactivity of pastes was determined by soaking them in simulated body fluid. Rheological behaviors of paste in both rotation and oscillation modes were also measured. The results showed that BG1 particles was microporous with mean pore diameter of 1.6 nm and particle size of ~300 nm while BG2 was mesoporous with average pore diameter of 8 and 17 nm and particle size of 20-30 nm. The paste made of BG2 revealed better washout resistance and in vitro apatite formation ability than BG1. According to the rheological evaluations, both pastes exhibited shear thinning but non-thixotropic behavior, meanwhile paste of BG2 had higher viscosity than BG1. The oscillatory tests revealed that the pastes were viscoelastic materials with more viscous nature. Both pastes could be completely injected through standard syringe using low compressive load of 5-50 N. Overall, The biocomposites can potentially be used as bioactive paste for the treatment of hard and even soft tissues.
采用酸催化（玻璃称为 BG1）和酸碱催化（BG2）溶胶-凝胶工艺合成了具有相同化学成分但颗粒特性不同的生物活性玻璃纳米粉末。通过 TEM 和 BET 方法确定了粉末的形态特征。将粉末分别与 3%透明质酸溶液混合形成糊剂。通过将糊剂浸泡在模拟体液中来测定其体外反应性。还测量了糊剂在旋转和振荡模式下的流变行为。结果表明，BG1 颗粒具有微孔结构，平均孔径为 1.6nm，粒径约为 300nm，而 BG2 为介孔结构，平均孔径为 8nm 和 17nm，粒径为 20-30nm。由 BG2 制成的糊剂显示出比 BG1 更好的耐洗脱性和体外磷灰石形成能力。根据流变学评估，两种糊剂均表现出剪切变稀但非触变行为，同时 BG2 糊剂的粘度高于 BG1 糊剂。振荡测试表明，糊剂为粘弹性材料，具有更粘的性质。两种糊剂都可以在低压缩负载 5-50N 下通过标准注射器完全注入。总的来说，生物复合材料有可能用作治疗硬组织甚至软组织的生物活性糊剂。
