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阿达木单抗诱发的成人 T 细胞白血病/淋巴瘤。

Adult T-cell leukemia/lymphoma triggered by adalimumab.

机构信息

Laboratory of Pathology. Complexo Hospitalar Universitário Prof. Edgard Santos, Federal University of Bahia, Rua Dr. Augusto Viana, s/n, Canela, CEP:40.110-060, Salvador, Bahia, Brazil.

出版信息

J Clin Virol. 2013 Oct;58(2):494-6. doi: 10.1016/j.jcv.2013.07.011. Epub 2013 Aug 1.

Abstract

Here, we describe a 48-year-old woman infected by the human T-cell lymphotropic virus type 1 (HTLV-1) with spondyloarthritis, uveitis, bilateral episcleritis and neurogenic bladder. She had a history of a probable infective dermatitis associated with HTLV-1 (IDH) in childhood. After the use of adalimumab, she developed lymphocytosis and a cutaneous lymphoma associated with IDH. She had the diagnoses of IDH and of chronic adult T-cell leukemia/lymphoma, supported by the demonstration of proviral integration in the cutaneous lesion.

摘要

这里,我们描述了一位 48 岁的女性,她感染了人类 T 细胞嗜淋巴细胞病毒 1 型(HTLV-1),伴有脊椎关节炎、葡萄膜炎、双侧表层巩膜炎和神经性膀胱炎。她在儿童时期曾患有可能与 HTLV-1(IDH)相关的感染性皮肤病。在使用阿达木单抗后,她出现了与 IDH 相关的淋巴细胞增多症和皮肤淋巴瘤。通过在皮肤病变中检测到前病毒整合,支持 IDH 和慢性成人 T 细胞白血病/淋巴瘤的诊断。

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