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具有整联蛋白选择性拟肽功能化纳米图案顶部的水凝胶微柱：一种用于测量通过 αvβ3-或 α5β1-整联蛋白传递的细胞牵引力的新工具。

Hydrogel micropillars with integrin selective peptidomimetic functionalized nanopatterned tops: a new tool for the measurement of cell traction forces transmitted through αvβ3- or α5β1-integrins.

机构信息

Department of New Materials and Biosystems, Max Planck Institute for Intelligent Systems, Heisenbergstr. 3, 70569, Stuttgart, Germany; Department of Biophysical Chemistry, University of Heidelberg, Im Neuenheimer Feld 253, 69120, Heidelberg, Germany.

出版信息

Adv Mater. 2013 Nov 6;25(41):5869-74. doi: 10.1002/adma.201301338. Epub 2013 Aug 5.

DOI:10.1002/adma.201301338
PMID:23913640
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3915041/
Abstract

Poly(ethylene glycol) micropillars with gold nanopatterns on top are functionalized with two integrin selective ligands. This platform is a powerful new tool to determine the specific contribution of traction forces involved in cell adhesion mediated by α5β1- and αvβ3-integrins. Cells adherent via α5β1-integrins have a tendency to exert higher maximum forces than cells adhering via αvβ3-integrins.

摘要

聚乙二醇（PEG）微柱的顶部具有金纳米图案，其功能化有两个整合素选择性配体。该平台是一种强大的新工具，可用于确定通过α5β1-和αvβ3-整合素介导的细胞黏附所涉及的牵引力的具体贡献。通过α5β1-整合素黏附的细胞施加的最大力倾向于高于通过αvβ3-整合素黏附的细胞。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ecd/4223998/befe2e7e181b/adma0025-5869-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ecd/4223998/4527034729f5/adma0025-5869-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ecd/4223998/95c29d5df2c0/adma0025-5869-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ecd/4223998/befe2e7e181b/adma0025-5869-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ecd/4223998/4527034729f5/adma0025-5869-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ecd/4223998/95c29d5df2c0/adma0025-5869-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ecd/4223998/befe2e7e181b/adma0025-5869-f3.jpg

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