Xyolide，一种源自亚马逊内生真菌的生物活性壬烯醇内酯。
Xyolide, a bioactive nonenolide from an Amazonian endophytic fungus, .
作者信息
Baraban Ezra G, Morin Jesse B, Phillips Gillian M, Phillips Andrew J, Strobel Scott A, Handelsman Jo
机构信息
Department of Molecular, Cellular, and Developmental Biology, Yale University, P.O. Box 208103, KBT 908 New Haven, CT, 06520 USA.
出版信息
Tetrahedron Lett. 2013 Jul 31;54(31):4058-4060. doi: 10.1016/j.tetlet.2013.05.093.
Abstract
Endophytes isolated from tropical plants represent a largely untapped reservoir of bioactive secondary metabolites. We screened a library of fungal endophyte extracts for inhibition of the plant pathogen, , and purified an active compound using bioassay-guided fractionation. A new nonenolide, ()-4--succinyl-7,8-dihydroxy-9-heptyl-nonen-9-olide, was isolated and named xyolide. The structure was elucidated by a combination of 1D and 2D NMR methods and the absolute configuration was determined by exciton-coupled circular dichroism. The MIC of xyolide against was 425 µM.
摘要
从热带植物中分离出的内生菌是生物活性次生代谢产物的一个很大程度上未被开发的来源。我们筛选了一个真菌内生菌提取物文库，以寻找对植物病原体的抑制作用，并使用生物测定引导的分级分离法纯化了一种活性化合物。分离出一种新的非烯内酯，（）-4-琥珀酰-7,8-二羟基-9-庚基-壬-9-烯内酯，并将其命名为xyolide。通过一维和二维核磁共振方法相结合阐明了其结构，并通过激子耦合圆二色性确定了绝对构型。xyolide对的最低抑菌浓度为425μM。
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