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具有抗微生物活性的内生真菌中的次生代谢产物。

Secondary metabolites from an endophytic fungus with antimicrobial activity towards .

机构信息

Laboratory of Biochemistry, Faculty of Science, University of Douala, Douala, Cameroon.

Department of Chemistry, University of Dschang, Dschang, Cameroon.

出版信息

Nat Prod Res. 2023 Feb;37(4):657-662. doi: 10.1080/14786419.2022.2075360. Epub 2022 May 18.

DOI:10.1080/14786419.2022.2075360
PMID:35583291
Abstract

Chemical investigation of the endophytic fungus, , isolated from healthy and asymptomatic common bean field crop, resulted in the isolation of a new alkene, ()-5-amino-5-(1,1,2-trihydroxybuta-1,3-dienyloxy)pentane-6,7,8,9-tetraol (), together with five known compounds (-). The structures of the compounds were elucidated by analysis of their spectroscopic data including 1 D, 2 D NMR, ESI-HRMS and literature data. The organic crude extract and the compound isolated from significantly (p ≤ 0.05) inhibited the mycelial growth of .

摘要

从健康无病的普通菜豆田间作物中分离到的内生真菌,经化学研究分离得到一种新的烯烃,() - 5-氨基-5-(1,1,2-三羟基丁-1,3-二烯氧基)戊烷-6,7,8,9-四醇(),以及五种已知化合物(-)。通过分析其光谱数据,包括 1D、2D NMR、ESI-HRMS 和文献数据,确定了化合物的结构。从 中分离得到的有机粗提取物和化合物显著(p≤0.05)抑制了 的菌丝生长。

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