Key Lab of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, No.8 Beiertiao, Zhongguancun, Haidian District, Beijing 100090, P. R. China.
Chem Biodivers. 2011 Sep;8(9):1689-700. doi: 10.1002/cbdv.201100026.
Three new sesquiterpene acids, xylaric acids A-C (1-3, resp.), and a new tetralone (=3,4-dihydronaphthalen-1(2H)-one) derivative, 4, along with nine known compounds, xylaric acid D (5), hydroheptelidic acid (6), gliocladic acid (7), chlorine heptelidic acid (8), trichoderonic acid A (9), 16-(α-D-mannopyranosyloxy)isopimar-7-en-19-oic acid (10), 16-(α-D-glucopyranosyloxy)isopimar-7-en-19-oic acid (11), 5-carboxymellein (12), and naphthalen-1,8-diol 1-O-α-D-glucopyranoside (13) have been isolated from the solid culture of the ascomycete fungus Xylaria sp. associated with termite nest. The structures of these compounds were elucidated primarily by NMR experiments. The absolute configurations of compounds 1-3 and 5-9 were determined by combination of X-ray data and CD spectral analysis. The absolute configuration of 4 was assigned by Snatzke's method. Compounds 8 and 11 showed slight cytotoxicities against two cell lines A549 and SGC7901.
从与白蚁巢共生的子囊菌真菌 Xylaria sp. 的固体培养物中分离得到了三种新的倍半萜酸，即木二酸 A-C（1-3），以及一种新的四氢萘酮 (=3,4-二氢萘-1(2H)-酮)衍生物 4，以及另外九种已知化合物，即木二酸 D（5）、海松酸（6）、地衣酸（7）、氯海松酸（8）、三齿酮酸 A（9）、16-（α-D-吡喃甘露糖氧基）异松-7-烯-19-酸（10）、16-（α-D-葡萄糖吡喃糖氧基）异松-7-烯-19-酸（11）、5-羧基美登木素（12）和萘-1,8-二醇 1-O-α-D-吡喃葡萄糖苷（13）。这些化合物的结构主要通过 NMR 实验阐明。通过 X 射线数据和 CD 光谱分析相结合，确定了化合物 1-3 和 5-9 的绝对构型。通过 Snatzke 法确定了 4 的绝对构型。化合物 8 和 11 对两种细胞系 A549 和 SGC7901 表现出轻微的细胞毒性。
