Jepsen J R, Stoyanov S, Unger M, Clausen J, Christensen H E
Acta Pathol Microbiol Scand A. 1977 Sep;85(5):731-8. doi: 10.1111/j.1699-0463.1977.tb00465.x.
Reports of skin malignancies due to occupational exposure have decreased since the introduction of solvent-refining of mineral oil fraction in the manufacture of oil based cutting fluids. Commercial mineral oil based cutting fluids caused local and general pathological changes after repeated application to the skin of mice in the present study. Forty-eight per cent of the mice exposed to oils showed severe dysplasia or malignancy of the skin on histological examination. The corresponding figure for the control group, where various additives were used was 8 per cent. The frequency of papillomas was also increased in the mice exposed to oils. The systemic lesions included focal necrosis of the liver, associated with amyloid deposition, as well as amyloidosis of the skin, spleen and kidneys. The substances responsible for these apparent carcinogenic properties of the complex mixtures may be polycyclic hydrocarbons; the latter are still present in the commercial products despite solvent refining; on the other hand the carcinogens may be additives to the cutting oils the composition of which is generally a trade secret.
自从在油基切削液制造中引入矿物油馏分的溶剂精制工艺后，职业暴露导致皮肤恶性肿瘤的报告有所减少。在本研究中，将市售的矿物油基切削液反复涂抹于小鼠皮肤后，会引发局部和全身的病理变化。组织学检查显示，接触油类的小鼠中有48%出现了严重的皮肤发育异常或恶性病变。使用各种添加剂的对照组的相应比例为8%。接触油类的小鼠中乳头状瘤的发生率也有所增加。全身性病变包括肝脏局灶性坏死，并伴有淀粉样沉积，以及皮肤、脾脏和肾脏的淀粉样变性。导致这些复杂混合物明显致癌特性的物质可能是多环烃；尽管经过溶剂精制，这些物质仍存在于市售产品中；另一方面，致癌物可能是切削油的添加剂，其成分通常是商业秘密。
