Tong Rong, Gabrielson Nathan P, Fan Timothy M, Cheng Jianjun
Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA.
Curr Opin Solid State Mater Sci. 2012 Dec 1;16(6):323-332. doi: 10.1016/j.cossms.2013.01.001.
Small molecule chemotherapeutics often have undesired physiochemical and pharmacological properties, such as low solubility, severe side effect and narrow therapeutic index. To address these challenges, polymeric nanomedicine drug delivery technology has been routinely employed, in particular with the use of biodegradable and biocompatible polyesters, such as poly(lactide) (PLA) and poly(lactide-co-glycolide) (PLGA). Here we review the development and use of PLA and PLGA for the delivery of chemotherapeutic agents in the forms of polymer-drug conjugates and nanoconjugates.
小分子化学疗法通常具有不理想的物理化学和药理特性，例如低溶解度、严重的副作用和狭窄的治疗指数。为应对这些挑战，聚合物纳米药物递送技术已被常规应用，特别是使用可生物降解和生物相容的聚酯，如聚乳酸（PLA）和聚乳酸-乙醇酸共聚物（PLGA）。在此，我们综述了PLA和PLGA在以聚合物-药物缀合物和纳米缀合物形式递送化疗药物方面的发展和应用。
