Department of Ophthalmology, Tokyo Medical University Hospital, Tokyo, Japan.
BMC Ophthalmol. 2013 Aug 6;13(1):38. doi: 10.1186/1471-2415-13-38.
Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon benign lesion, primarily occurring in the head and neck. ALHE arising from the ocular adnexa is rare, and the bilateral presentation is especially rare in the eyelids.
A 64-year-old Japanese man presented with tearing. Multiple nodules, approximately 5 mm in size, were observed in bilateral upper and lower eyelids. Surgical excisions of the both eyelids masses were performed. Histopathological examination of the excised masses demonstrated proliferated blood vessels lined by plump endothelial cells together with a lymphoid and eosinopilic infiltrate, compatible with a diagnosis of ALHE. Flow cytometry studies showed that the mass consisted of mostly CD3-positive cells. During two-year follow-up, no recurrence of the mass was observed and the patient had no subjective symptom of tearing
ALHE may occur in the bilateral eyelids. The cause of ALHE remains uncertain, but our results of flow cytemetry suggest that T cells are related to the pathogenesis of this disease.
血管淋巴样增生伴嗜酸性粒细胞增多症（ALHE）是一种不常见的良性病变，主要发生在头颈部。发生于眼部附属器的 ALHE 较为罕见，双侧发生于眼睑者尤其罕见。
一名 64 岁日本男性因流泪就诊。双侧上、下眼睑可见多个约 5mm 大小的结节。行双眼睑肿物切除术。切除的肿物组织病理学检查显示增生的血管由饱满的内皮细胞排列，伴有淋巴和嗜酸性粒细胞浸润，符合 ALHE 的诊断。流式细胞术研究显示，肿块主要由 CD3 阳性细胞组成。在两年的随访中，未观察到肿块复发，患者也没有流泪的主观症状。
ALHE 可发生于双侧眼睑。ALHE 的病因尚不确定，但我们的流式细胞术结果提示 T 细胞与该病的发病机制有关。
