非功能性甲状旁腺癌的高度侵袭性病理。

Department of Nuclear Medicine and Endocrine Tumours, Ion Chiricuţă Institute of Oncology, 34-36, Republicii St, 400015, Cluj-Napoca, România.

Orphanet J Rare Dis. 2013 Aug 3;8:115. doi: 10.1186/1750-1172-8-115.

Parathyroid carcinoma is a rare malignant endocrine tumor accounting for only 0.5% to 5% of all primary hyperparathyroidism. Among these malignancies, only 10-25% are nonfunctioning. After the review of the literature we could only ascertain a number of 25 cases reported worldwide, since 1929, our case being the 26th, but the first with a very aggressive pathology, treated with chemotherapy scheme usually used for neuroendocrine tumors. Considering these facts, every single case presented is a step forward in defying the clinical presentation, for the awareness of the clinicians, and also in establishing standard adjuvant therapies.

甲状旁腺癌是一种罕见的恶性内分泌肿瘤，仅占所有原发性甲状旁腺功能亢进症的 0.5%至 5%。在这些恶性肿瘤中，仅有 10-25%是非功能性的。通过对文献的回顾，我们仅确定了自 1929 年以来全世界报告的 25 例病例，我们的病例是第 26 例，但却是首例具有非常侵袭性病理的病例，采用了通常用于神经内分泌肿瘤的化疗方案进行治疗。考虑到这些事实，每一个呈现的病例都代表着在挑战临床表现、提高临床医生认识方面迈出了一步，也为确立标准辅助治疗方法奠定了基础。