蓝莓叶多糖对链脲佐菌素诱导的糖尿病小鼠的降血糖作用。
Anti-diabetic activity of Vaccinium bracteatum Thunb. leaves' polysaccharide in STZ-induced diabetic mice.
机构信息
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Jiangsu, Wuxi, 214122, China.
出版信息
Int J Biol Macromol. 2013 Oct;61:317-21. doi: 10.1016/j.ijbiomac.2013.07.028. Epub 2013 Aug 2.
Vaccinium bracteatum Thunb. (VBT) is a traditional Chinese herbal medicine. The anti-diabetic activity of VBT leaves' polysaccharide (VBTLP) is studied in this paper. The results indicated VBTLP had a dose-dependent decrease on the blood glucose (BG) level, and the time effect of VBTLP on BG level was also significant. The insulin level of high dose group (HDG) was significantly higher (p<0.05) than that of model control (MC) group. Compared to MC, HDG and lose dose group (LDG) had significantly lower (p<0.05) TC and LDL-C levels, however, TG and HDL-C levels are similar. Compared to non-diabetic control (NC), HDG and LDG had similar plasma lipid levels except for higher LDL-C level. Although body weights of LDG and HDG were significant lower (p<0.05) than that of NC from week 2 to week 6, they were similar to that of PC. The results indicate VBTLP possesses a potential hypoglycemic effect in streptozotocin-induced diabetic mice.
变叶海棠（VBT）是一种传统的中草药。本研究探讨了 VBT 叶多糖（VBTLP）的降血糖活性。结果表明，VBTLP 对血糖（BG）水平有剂量依赖性降低作用，且 VBTLP 对 BG 水平的时间效应也很显著。高剂量组（HDG）的胰岛素水平明显高于模型对照组（MC）（p<0.05）。与 MC 相比，HDG 和低剂量组（LDG）的 TC 和 LDL-C 水平明显降低（p<0.05），而 TG 和 HDL-C 水平相似。与正常对照组（NC）相比，除 LDL-C 水平较高外，HDG 和 LDG 的血浆脂质水平相似。尽管 LDG 和 HDG 的体重从第 2 周到第 6 周均明显低于 NC（p<0.05），但与 PC 相似。结果表明，VBTLP 对链脲佐菌素诱导的糖尿病小鼠具有潜在的降血糖作用。
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