木薯交联辛烯基琥珀酸麦芽糊精在 STZ 诱导的糖尿病小鼠中的抗糖尿病活性。
Anti-diabetic activity of cassava cross-linked octenyl succinic maltodextrin in STZ-induced diabetic mice.
机构信息
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, Jiangsu, China.
Wuxi Cofco Engineering & Technology Co., Ltd., Wuxi 214036, Jiangsu, China.
出版信息
Int J Biol Macromol. 2014 Mar;64:247-51. doi: 10.1016/j.ijbiomac.2013.11.017. Epub 2013 Dec 1.
The effect of cassava cross-linked octenyl succinic maltodextrin (CCOMD) on diabetic mice was investigated in this study. For CCOMD-L (low dose) and CCOMD-H (high dose) groups, the body weights were recovered by 14.9% and 18.5%, respectively, which were significantly higher than that of model control group. It was also found that the blood glucose and insulin levels were ameliorated in the diabetic mice by the CCOMD diet. Moreover, the CCOMD diet decreased the plasma total cholesterol level (8.1-9.1%) and LDL cholesterol level (28.9-39.4%), and improved the plasma HDL cholesterol level (13.8-15.3%) and intestine short chain fatty acid content. The results indicated that CCOMD administration may be helpful for treating and preventing hyperlipidemia and hyperglycemia in diabetes.
本研究旨在探讨木薯交联辛烯基琥珀酸麦芽糊精（CCOMD）对糖尿病小鼠的影响。对于 CCOMD-L（低剂量）和 CCOMD-H（高剂量）组，体重分别恢复了 14.9%和 18.5%，明显高于模型对照组。研究还发现，CCOMD 饮食可改善糖尿病小鼠的血糖和胰岛素水平。此外，CCOMD 饮食降低了血浆总胆固醇水平（8.1-9.1%）和 LDL 胆固醇水平（28.9-39.4%），并改善了血浆 HDL 胆固醇水平（13.8-15.3%）和肠道短链脂肪酸含量。结果表明，CCOMD 的给药可能有助于治疗和预防糖尿病的高血脂和高血糖。
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