Department of Animal Reproduction Biotechnology and Environmental Hygiene, West Pomeranian University of Technology in Szczecin, Judyma 6 Street, 71-466, Szczecin, Poland,
Environ Monit Assess. 2014 Jan;186(1):229-38. doi: 10.1007/s10661-013-3368-z. Epub 2013 Aug 7.
The aim of this study was to detect the presence and determine the residue levels of DDT, lindane, endrin and polychlorinated biphenyls (PCBs) in the liver of wild boars from the area of West Pomerania, NW Poland; to determine the activity of glutathione S-transferase (GST) as a biomarker of biological response and to assess the toxicological risk for consumers of the wild boar offal. The presence of pesticide residues and PCBs was found in all examined liver samples. The highest concentration was observed for endrin, and then, the descending order was PCBs >DDTs >lindane >dl-PCBs. The mean hepatic concentrations of endrin, PCBs, DDTs and lindane were 117.28, 78.59, 67.95 and 7.24 ng/g lipid weight, respectively. Among the dioxin-like PCB congeners, 118 and 156 were dominant in liver samples. The mean toxic equivalent (TEQ) level calculated for dl-PCBs was 2.10 ± 1.11 pg WHO-PCB-TEQ/g. There was a statistically significant (p < 0.05) negative correlation between the concentration of lindane, DDTs and PCBs (as a sum of indicator congeners) in the liver and in the activity of GST. However, GST activities showed no significant correlation with any of the dl-PCBs. In five boar liver samples, the levels of certain organochlorine compounds exceeded the maximum residue levels (MRLs). In one sample, the MRLs were exceeded simultaneously for PCBs, endrin and DDTs and in another one-for endrin and DDTs. In the remaining three samples, only PCB levels were exceeded.
本研究旨在检测波兰西北部西波美拉尼亚地区野猪肝脏中滴滴涕、林丹、异狄氏剂和多氯联苯（PCBs）的存在情况和残留水平；测定谷胱甘肽 S-转移酶（GST）的活性，作为生物反应的生物标志物，并评估野猪肉毒理学风险。在所有检测的肝样中均发现了农药残留和 PCBs。异狄氏剂的浓度最高，其次是 PCBs>滴滴涕>林丹>dl-PCBs。异狄氏剂、PCBs、滴滴涕和林丹在肝中的平均浓度分别为 117.28、78.59、67.95 和 7.24ng/g 脂重。在二噁英类 PCBs 同系物中，118 和 156 在肝样中占主导地位。计算出的 dl-PCBs 总毒性当量（TEQ）水平为 2.10±1.11pg WHO-PCBs-TEQ/g。肝中林丹、滴滴涕和 PCBs（作为指示同系物的总和）浓度与 GST 活性之间存在统计学显著（p<0.05）的负相关。然而，GST 活性与任何一种 dl-PCBs 均无显著相关性。在 5 个野猪肝样中，某些有机氯化合物的水平超过了最大残留限量（MRLs）。在一个样本中，PCBs、异狄氏剂和滴滴涕同时超过了 MRLs，而在另一个样本中，异狄氏剂和滴滴涕同时超过了 MRLs。在其余三个样本中，仅超过了 PCB 水平。
