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一般老年人群中的跌倒:使用来自斯科讷纵向人群研究“良好衰老在斯科讷”的数据进行的 3 年和 6 年前瞻性研究风险因素。

Falls in the general elderly population: a 3- and 6- year prospective study of risk factors using data from the longitudinal population study 'Good ageing in Skane'.

机构信息

Department of Health Sciences, Division of Geriatric Medicine, Lund University, Skåne University Hospital, Malmö SE-205 02, Sweden.

出版信息

BMC Geriatr. 2013 Aug 7;13:81. doi: 10.1186/1471-2318-13-81.

Abstract

BACKGROUND

Accidental falls in the elderly are a major health problem, despite extensive research on risk factors and prevention. Only a limited number of multifactorial, long-term prospective studies have been performed on risk factors for falls in the general elderly population. The aim of this study was to identify risk factors predicting falls in a general elderly population after three and six years, using a prospective design.

METHODS

The prevalence of 38 risk factors was recorded at a baseline assessment of 1763 subjects (aged 60-93 years). The incidence of one or more falls was recorded after three and six years. The predicted risk of falling, after exposure to the various risk factors, was analysed in a multiple logistic regression model, adjusted for age and sex, and presented as odds ratios (OR). A principal component analysis (PCA), including the statistical significant factors, was also performed to identify thematic, uncorrelated components associated with falls.

RESULTS

The use of neuroleptics (OR 3.30, 95% CI: 1.15-9.43), heart failure with symptoms (OR 1.88, 95% CI: 1.17-3.04) and low walking speed (OR 1.77, 95% CI: 1.28-2.46) were prominent individual risk factors for falls. In the PCA, three main components predicting falls were identified: reduced mobility, OR 2.12 (95% CI 1.54-2.91), heart dysfunction, OR 1.66 (95% CI 1.26-2.20) and functional impairment including nocturia, OR 1.38 (95% CI 1.01-1.88).

CONCLUSIONS

Three main components predicting falls were identified in a general elderly population after three and six years: reduced mobility, heart dysfunction and functional impairment including nocturia. The use of neuroleptic drugs was also a prominent individual risk factor, although the prevalence was low. Heart failure with symptoms was a significant risk factor for falls and may be of clinical importance as the prevalence of this condition in the elderly is increasing worldwide. There is need for further research on the relation between heart failure and falls in the elderly, as the treatment for this condition is poorly documented in this demographic. The findings of this study may be valuable in the development of intervention programmes aimed at sustainable, long-term reduction of falls in the elderly.

摘要

背景

尽管对危险因素和预防措施进行了广泛的研究,但老年人意外跌倒仍是一个重大的健康问题。只有少数多因素、长期前瞻性研究针对一般老年人群跌倒的危险因素进行了研究。本研究旨在采用前瞻性设计,确定一般老年人群在 3 年和 6 年后跌倒的预测因素。

方法

在 1763 名(年龄 60-93 岁)受试者的基线评估中记录了 38 种危险因素的患病率。在 3 年和 6 年后记录了一次或多次跌倒的发生情况。在调整了年龄和性别后,通过多因素逻辑回归模型分析了暴露于各种危险因素后跌倒的预测风险,并以比值比(OR)表示。还进行了主成分分析(PCA),其中包括统计学显著的因素,以确定与跌倒相关的主题、不相关的成分。

结果

使用神经安定药(OR 3.30,95%CI:1.15-9.43)、有症状的心衰(OR 1.88,95%CI:1.17-3.04)和低步行速度(OR 1.77,95%CI:1.28-2.46)是跌倒的显著个体危险因素。在 PCA 中,确定了三个主要的跌倒预测因素:活动能力降低,OR 2.12(95%CI 1.54-2.91)、心脏功能障碍,OR 1.66(95%CI 1.26-2.20)和包括夜尿在内的功能障碍,OR 1.38(95%CI 1.01-1.88)。

结论

在一般老年人群中,在 3 年和 6 年后确定了三个主要的跌倒预测因素:活动能力降低、心脏功能障碍和包括夜尿在内的功能障碍。使用神经安定药也是一个显著的个体危险因素,尽管其患病率较低。有症状的心衰是跌倒的一个显著危险因素,由于这种情况在全球老年人群中的患病率不断增加,因此可能具有临床重要性。需要进一步研究老年人心衰与跌倒之间的关系,因为这种情况下的治疗方法在这一人群中记录不佳。本研究的结果可能对制定旨在可持续降低老年人跌倒风险的干预计划具有重要价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a21/3750524/7d56c15c89fb/1471-2318-13-81-1.jpg

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