大果木鳖（Phaleria macrocarpa (Scheff.) Boerl.）提取物的植物化学与药用特性
Phytochemistry and medicinal properties of Phaleria macrocarpa (Scheff.) Boerl. extracts.
作者信息
Altaf Rabia, Asmawi Mohammad Zaini Bin, Dewa Aidiahmad, Sadikun Amirin, Umar Muhammad Ihtisham
机构信息
Department of Pharmacology, School of Pharmaceutical Sciences, University Sains Malaysia, Minden, Pulau Pinang, Malaysia.
出版信息
Pharmacogn Rev. 2013 Jan;7(13):73-80. doi: 10.4103/0973-7847.112853.
Abstract
Phaleria macrocarpa, commonly known as Mahkota dewa is a medicinal plant that is indigenous to Indonesia and Malaysia. Extracts of P. macrocarpa have been used since years in traditional medicine that are evaluated scientifically as well. The extracts are reported for a number of valuable medicinal properties such as anti-cancer, anti-diabetic, anti-hyperlipidemic, anti-inflammatory, anti-bacterial, anti-fungal, anti-oxidant and vasorelaxant effect. The constituents isolated from different parts of P. macrocarpa include Phalerin, gallic acid, Icaricide C, magniferin, mahkoside A, dodecanoic acid, palmitic acid, des-acetylflavicordin-A, flavicordin-A, flavicordin-D, flavicordin-A glucoside, ethyl stearate, lignans, alkaloids andsaponins. The present review is an up-to-date summary of occurrence, botanical description, ethnopharmacology, bioactivity and toxicological studies related to P. macrocarpa.
摘要
大果木鳖，俗称“神果”，是一种原产于印度尼西亚和马来西亚的药用植物。多年来，大果木鳖提取物一直在传统医学中使用，并且也经过了科学评估。据报道，这些提取物具有多种宝贵的药用特性，如抗癌、抗糖尿病、抗高血脂、抗炎、抗菌、抗真菌、抗氧化和血管舒张作用。从大果木鳖不同部位分离出的成分包括木鳖素、没食子酸、驱虫菊酯C、异芒果素、大果木鳖苷A、十二烷酸、棕榈酸、去乙酰黄酮苷-A、黄酮苷-A、黄酮苷-D、黄酮苷-A葡萄糖苷、硬脂酸乙酯、木脂素、生物碱和皂苷。本综述是关于大果木鳖的分布、植物描述、民族药理学、生物活性和毒理学研究的最新总结。
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1
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Molecules. 2012 Apr 30;17(5):4986-5002. doi: 10.3390/molecules17054986.
2
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3
Effect of phaleria macrocarpa supplementation on apoptosis and tumor growth of C3H mice with breast cancer under treatment with adriamycin-cyclophosphamide.
Int Surg. 2011 Apr-Jun;96(2):164-70. doi: 10.9738/1404.1.
4
Phaleria macrocarpa (Scheff.) Boerl fruit aqueous extract enhances LDL receptor and PCSK9 expression in vivo and in vitro.
J Ethnopharmacol. 2011 Sep 1;137(1):817-27. doi: 10.1016/j.jep.2011.06.041. Epub 2011 Jul 5.
5
Symptomatic treatment of premenstrual syndrome and/or primary dysmenorrhea with DLBS1442, a bioactive extract of Phaleria macrocarpa.
Int J Gen Med. 2011;4:465-76. doi: 10.2147/IJGM.S21053. Epub 2011 Jun 16.
6
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Int J Mol Sci. 2011;12(6):3422-31. doi: 10.3390/ijms12063422. Epub 2011 May 27.
7
A review on the dietary flavonoid kaempferol.
Mini Rev Med Chem. 2011 Apr;11(4):298-344. doi: 10.2174/138955711795305335.
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DLBS1425, a Phaleria macrocarpa (Scheff.) Boerl. extract confers anti proliferative and proapoptosis effects via eicosanoid pathway.
J Exp Ther Oncol. 2010;8(3):187-201.
9
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10
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