von Woedtke Th, Haertel B, Weltmann K-D, Lindequist U
Leibniz Institute for Plasma Science and Technology e.V., Greifswald, Germany.
Pharmazie. 2013 Jul;68(7):492-8.
During the last years the use of physical plasma for medical applications has grown rapidly. A multitude of findings about plasma-cell and plasma-tissue interactions and its possible use in therapy have been provided. One of the key findings of plasma medical basic research is that several biological effects do not result from direct plasma-cell or plasma-tissue interaction but are mediated by liquids. Above all, it was demonstrated that simple liquids like water or physiological saline, are antimicrobially active after treatment by atmospheric pressure plasma and that these effects are attributable to the generation of different low-molecular reactive species. Besides, it could be shown that plasma treatment leads to the stimulation of specific aspects of cell metabolism and to a transient and reversible increase of diffusion properties of biological barriers. All these results gave rise to think about another new and innovative field of medical plasma application. In contrast to plasma medicine, which means the direct use of plasmas on or in the living organism for direct therapeutic purposes, this field - as a specific field of medical plasma application - is called plasma pharmacy. Based on the present state of knowledge, most promising application fields of plasma pharmacy might be: plasma-based generation of biologically active liquids; plasma-based preparation, optimization, or stabilization of - mainly liquid - pharmaceutical preparations; support of drug transport across biological barriers; plasma-based stimulation of biotechnological processes.
在过去几年中，物理等离子体在医学应用中的使用迅速增长。关于等离子体-细胞和等离子体-组织相互作用及其在治疗中可能应用的大量研究结果已经得出。等离子体医学基础研究的关键发现之一是，几种生物学效应并非源于直接的等离子体-细胞或等离子体-组织相互作用，而是由液体介导的。最重要的是，研究表明，像水或生理盐水这样的简单液体在经过大气压等离子体处理后具有抗菌活性，并且这些效应归因于不同低分子反应性物质的产生。此外，还可以证明等离子体处理会刺激细胞代谢的特定方面，并导致生物屏障扩散特性的短暂和可逆增加。所有这些结果促使人们思考医学等离子体应用的另一个新的创新领域。与将等离子体直接用于生物体上或体内以达到直接治疗目的的等离子体医学不同，这个领域——作为医学等离子体应用的一个特定领域——被称为等离子体药学。基于目前的知识水平，等离子体药学最有前景的应用领域可能是：基于等离子体生成生物活性液体；基于等离子体制备、优化或稳定——主要是液体——药物制剂；支持药物跨生物屏障的运输；基于等离子体刺激生物技术过程。
