Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao, 266003, PR China.
Org Lett. 2013 May 3;15(9):2168-71. doi: 10.1021/ol400694h. Epub 2013 Apr 3.
Three prenylated indole alkaloids with a rare anti bicyclo-[2.2.2]diazaoctane core ring (5-7) were isolated from Aspergillus taichungensis. The structures including absolute configurations were elucidated based on NMR, X-ray, and CD methods. (+)-Versicolamides B and C (8-9) which contain a spiro-center, together with seven analogues (7, 10-15), were isolated as photoinduced conversion products of 6. Biological evaluation indicated that 6 and 7 exhibited significant cytotoxicities with IC50 values in the low micromolar range.
从台中被曲霉菌中分离得到三种具有罕见双环-[2.2.2]辛烷核心环（5-7）的prenylated 吲哚生物碱。基于 NMR、X 射线和 CD 方法阐明了包括绝对构型在内的结构。(+)-Versicolamides B 和 C（8-9）含有一个 spiro 中心，以及七个类似物（7、10-15），作为 6 的光诱导转化产物被分离出来。生物评价表明，6 和 7 表现出显著的细胞毒性，IC50 值在低微摩尔范围内。
