荧光引导手术与实时分子导航——新的前沿技术。
Fluorescence-guided surgery with live molecular navigation--a new cutting edge.
机构信息
The Division of Otolaryngology-Head and Neck Surgery, University of California at San Diego, La Jolla, California 92093-0647, USA.
出版信息
Nat Rev Cancer. 2013 Sep;13(9):653-62. doi: 10.1038/nrc3566. Epub 2013 Aug 8.
Abstract
A glowing new era in cancer surgery may be dawning. Using fluorescently labelled markers, surgical molecular navigation means that tumours and nerves can be displayed in real time intra-operatively in contrasting pseudocolours, which allows more complete tumour resection while preserving important structures. These advances can potentially cause a paradigm shift in cancer surgery, improving patient outcome and decreasing overall health-care costs.
摘要
癌症手术领域可能迎来一个崭新的发光时代。通过荧光标记物，手术分子导航技术能够在术中实时以不同伪彩显示肿瘤和神经，从而在保留重要结构的同时实现更彻底的肿瘤切除。这些进展可能会彻底改变癌症手术模式，改善患者预后并降低整体医疗成本。
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2
Fluorescence imaging in surgery.手术中的荧光成像。
IEEE Rev Biomed Eng. 2013;6:178-87. doi: 10.1109/RBME.2013.2240294. Epub 2013 Jan 15.
3
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4
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