Soga Satoko, Ota Noriyasu, Shimotoyodome Akira
Biological Science Research, Kao Corporation.
Biosci Biotechnol Biochem. 2013;77(8):1633-6. doi: 10.1271/bbb.130147. Epub 2013 Aug 7.
Long-term ingestion of coffee polyphenols (chlorogenic acids, CGAs) reduces body fat in humans and rodents. While CGA supplementation has been shown to increase fat utilization in rodents, evidence in humans is still limited. The present study clarifies the effect of daily CGA consumption on energy metabolism in humans. Eighteen healthy male subjects (36.1 ± 7.4 y of age) participated in a placebo-controlled, double-blind, crossover, intervention study with two different test beverages. The subjects consumed 185 mL of a test beverage with or without CGAs (329 mg) daily for 4 wk. The energy metabolism was evaluated by using indirect calorimetry before and after the test period during fasting and up to 180 min postprandially. Indirect calorimetry showed that a 4-wk ingestion of the CGA beverage led to a significantly higher postprandial energy expenditure than that of the control beverage. The subjects ingesting the CGA beverage exhibited higher postprandial fat utilization than those consuming the control beverage. The daily CGA consumption therefore increased postprandial fat utilization in healthy humans.
长期摄入咖啡多酚（绿原酸，CGAs）可减少人类和啮齿动物的体脂。虽然补充CGA已被证明可提高啮齿动物的脂肪利用率，但在人类中的证据仍然有限。本研究阐明了每日摄入CGA对人类能量代谢的影响。18名健康男性受试者（年龄36.1±7.4岁）参与了一项安慰剂对照、双盲、交叉干预研究，使用两种不同的测试饮料。受试者每天饮用185毫升含或不含CGA（329毫克）的测试饮料，持续4周。在测试期前后的空腹状态以及餐后长达180分钟期间，使用间接量热法评估能量代谢。间接量热法显示，摄入CGA饮料4周后，餐后能量消耗显著高于对照饮料。摄入CGA饮料的受试者比饮用对照饮料的受试者表现出更高的餐后脂肪利用率。因此，每日摄入CGA可提高健康人的餐后脂肪利用率。
