Health & Wellness Products Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan.
Department of Research & Development, Kao Corporation, Tokyo 131-8501, Japan.
Nutrients. 2020 Dec 7;12(12):3757. doi: 10.3390/nu12123757.
A reduction in estrogen levels in the perimenopausal and postmenopausal periods causes various symptoms in women, such as hot flushes, sweats, depression, anxiety, and insomnia. Chlorogenic acids (CGAs), which are phenolic compounds widely present in plants such as coffee beans, have various physiological functions. However, the effects of CGAs on menopausal symptoms are unknown. To examine the effects of CGAs on menopausal symptoms, especially hot flushes, a randomized, placebo-controlled, double-blind, parallel-group trial was conducted in healthy women. Eighty-two subjects were randomized and assigned to receive CGAs (270 mg) tablets or the placebo for 4 weeks. After 4 weeks of intake, the number of hot flushes, the severity of hot flushes during sleep, and the severity of daytime sweats decreased significantly in the CGA group compared to the placebo group. The modified Kupperman index for menopausal symptoms decreased significantly after 2 weeks in the CGA group compared to the placebo group. Adverse effects caused by CGAs were not observed. The results show that continuous intake of CGAs resulted in improvements in menopausal symptoms, especially hot flushes, in healthy women.
围绝经期和绝经后雌激素水平下降会导致女性出现各种症状，如热潮红、出汗、抑郁、焦虑和失眠。绿原酸（CGAs）是一种广泛存在于咖啡豆等植物中的酚类化合物，具有多种生理功能。然而，CGAs 对更年期症状的影响尚不清楚。为了研究 CGAs 对更年期症状，特别是热潮红的影响，进行了一项随机、安慰剂对照、双盲、平行组试验，纳入了健康女性。82 名受试者被随机分配并接受 CGAs（270mg）片剂或安慰剂，为期 4 周。在摄入 4 周后，与安慰剂组相比，CGAs 组的热潮红次数、睡眠期间热潮红的严重程度和白天出汗的严重程度均显著下降。与安慰剂组相比，CGAs 组的改良 Kupperman 更年期症状指数在 2 周后显著下降。未观察到 CGAs 引起的不良反应。结果表明，连续摄入 CGAs 可改善健康女性的更年期症状，特别是热潮红。
