1Jewish Hospital Cholesterol Center, Jewish Hospital of Cincinnati, Cincinnati, OH, USA.
Clin Appl Thromb Hemost. 2014 Apr;20(3):244-9. doi: 10.1177/1076029613499819. Epub 2013 Aug 7.
In our study of 596 men hospitalized in the last 3 years for deep venous thrombosis-pulmonary emboli (DVT-PE), we determined the prevalence of exogenous testosterone (T) use with subsequent development of DVT-PE. Of the 596 men, 110 were now dead, 97 had cancer thought to cause DVT-PE, 250 could not be contacted, leaving 139, of whom 7 had taken T before and at the time of their admissions, 1.2% of the total cohort, a conservative estimate of the prevalence of T-associated DVT-PE. In all, 5 of the 7 DVT-PE events occurred within 3 months of initiation of T, with mean and median intervals between initiation of T and hospitalization with DVT-PE 6.7 and 2 months. Of the 7 men treated with exogenous T, all 5 men who had evaluation of thrombophilia-hypofibrinolysis were found to have previously undiagnosed familial or acquired thrombophilia or hypofibrinolysis, suggesting a thrombotic interaction between exogenous T and thrombophilia-hypofibrinolysis.
在对过去 3 年中因深静脉血栓形成-肺栓塞（DVT-PE）住院的 596 名男性进行的研究中，我们确定了外源性睾酮（T）使用与随后发生 DVT-PE 的患病率。在这 596 名男性中，110 人已经死亡，97 人患有被认为会导致 DVT-PE 的癌症，250 人无法联系，剩下 139 人，其中 7 人在入院前和入院时服用了 T，占总队列的 1.2%，这是 T 相关 DVT-PE 的患病率的保守估计。总的来说，7 例 DVT-PE 事件中有 5 例发生在开始使用 T 的 3 个月内，T 开始使用和 DVT-PE 住院之间的平均和中位数间隔分别为 6.7 个月和 2 个月。在接受外源性 T 治疗的 7 名男性中，所有 5 名接受血栓形成-纤溶异常评估的男性均被发现先前患有未诊断的家族性或获得性血栓形成或纤溶异常，这表明外源性 T 与血栓形成-纤溶异常之间存在血栓相互作用。
