Department of Oncology, Herlev Hospital, University of Copenhagen, Herlev Ringvej 75, DK-2730, Herlev, Denmark,
Support Care Cancer. 2013 Dec;21(12):3363-70. doi: 10.1007/s00520-013-1916-2. Epub 2013 Aug 8.
The do-not-resuscitate decision is a common ethical problem. However, the concordance between patients' preferences and physicians' assessments of the indication for cardiopulmonary resuscitation attempt (CPR) has only been modestly investigated.
The purpose of this study was to determine the impact of different patient characteristics on the following outcomes: (1) patients' wishes for or against CPR, (2) assessments made by physicians of the indication for CPR, and (3) the probability of discordance between patients' wishes and physicians' assessments.
In this survey, 1,128 of 1,408 cancer patients received a questionnaire concerning their wish for CPR. In total, 904 patients responded. A total of 61 treating physicians assessed the medical indication for resuscitation. Different predefined patient characteristics were analyzed using both univariate and multivariate analyses.
Ninety percent of responding patients wished to receive CPR. The physicians found indications supporting CPR in 89 % of patients. Age ≥70 years, increasing line of treatment, poor prognosis, living alone, and poor self-rated physical and mental health enhanced both patients' wishes and physicians' assessments to withhold CPR. However, only age ≥70 years, poor prognosis, and poor self-rated physical health significantly predicted rejection of CPR in multivariate analyses. The likelihood of discordance between patients and physicians was significantly higher when the patient was ≥70 years and when the expected 5-year survival was <25 %.
Factors associated with the imminence of dying influenced both patients and physicians to refrain from CPR, and perhaps more surprisingly, the probability of discordance between patients and physicians increased.
不复苏决策是一个常见的伦理问题。然而,患者的偏好与医生对心肺复苏(CPR)尝试指征的评估之间的一致性仅得到了适度的研究。
本研究的目的是确定不同患者特征对以下结果的影响:(1)患者对 CPR 的意愿或反对,(2)医生对 CPR 指征的评估,以及(3)患者意愿与医生评估之间不相符的可能性。
在这项调查中,1408 名癌症患者中有 1128 名收到了一份关于他们对 CPR 意愿的问卷。共有 904 名患者做出了回应。共有 61 名主治医生评估了复苏的医学指征。使用单变量和多变量分析分析了不同的预设患者特征。
90%的回应患者希望接受 CPR。医生在 89%的患者中发现了支持 CPR 的指征。年龄≥70 岁、治疗线增加、预后不良、独居以及身体和心理健康自评较差,均增强了患者和医生对不进行 CPR 的意愿和评估。然而,只有年龄≥70 岁、预后不良和身体自评健康状况较差在多变量分析中显著预测了 CPR 的拒绝。当患者≥70 岁且预期 5 年生存率<25%时,患者和医生之间不相符的可能性显著增加。
与死亡迫近相关的因素影响了患者和医生对不进行 CPR 的决定,更令人惊讶的是,患者和医生之间不相符的可能性增加了。